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research Synthesis and biological evaluation of esters of 16-formyl-17-methoxy-dehydroepiandrosterone derivatives as inhibitors of 5α-reductase type 2

5 citations , November 2015 in “Journal of Enzyme Inhibition and Medicinal Chemistry”

This study found that aliphatic ester moieties in 16-formyl-17-methoxy dehydroepiandrosterone derivatives increased their potency as 5α-reductase type 2 inhibitors in vitro compared to finasteride.

research Effect of C-ring modifications in benzo[c]quinolizin-3-ones, new selective inhibitors of human 5α-reductase 1

12 citations , June 2001 in “Bioorganic & Medicinal Chemistry”

This study found that octahydrobenzo[c]quinolizin-3-one derivatives, particularly compound 3, were potent and selective inhibitors of the enzyme 5α-reductase type 1.

research Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5α-reductases 1 and 2

9 citations , November 2004 in “Bioorganic & Medicinal Chemistry Letters”

This study identified potent dual inhibitors of 5α-reductases 1 and 2 that may aid in designing new drugs for related diseases.

research Stable isotope analyses of carbon and nitrogen in hair keratin of suspected man-eating wolves from 1880s

February 2024 in “Scientific Reports”

The wolves suspected of man-eating in the 1880s likely ate very little human flesh and mostly consumed a diet similar to herbivores and omnivores.

research Aromatic C-nitrosation of a bioactive molecule. Nitrosation of minoxidil

8 citations , January 2011 in “Organic and Biomolecular Chemistry”

Minoxidil reacts to nitrosation 7 times more than phenol, mainly due to its -NH₂ groups, leading to the creation of N-nitrosominoxidil.

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Community Join

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community 3 years with Minoxidil and finasteride and 8 prp sessions

in Finasteride/Dutasteride 201 upvotes 4 months ago

Minoxidil and finasteride have stabilized hair loss but not significantly improved regrowth. The user is considering dutasteride, oral Minoxidil, or a hair transplant for better results.

community My hair after 3 steroid cycles

in Progress Pictures 27 upvotes 2 years ago

A user shared their hair progress after three steroid cycles, using 5% minoxidil and 100mg RU58841 daily. They are considering a hair transplant due to paranoia about shedding.

community Switching to oral minoxidil and dus, after 3 year years of oral fin and topical min?

in Basic Questions 224 upvotes 1 week ago

The user is considering switching from topical minoxidil and finasteride to oral minoxidil and dutasteride for hair loss treatment. They are also contemplating adding microneedling to their routine and are seeking advice from others with similar experiences.

community Comprehensive Microneedling Guide

292 upvotes 4 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community Long Post (Sorry): Regarding Finasteride usage based on your decision

in Finasteride 375 upvotes 1 year ago

The user experienced significant hair regrowth using finasteride and minoxidil but developed erectile dysfunction. They are considering stopping finasteride and relying on minoxidil alone to see if the side effects improve.

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Learn

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learn Scalp Micropigmentation

Does scalp micropigmentation hurt? Providers say SMP usually causes mild discomfort, often described as light scratching. No published study has measured pain during SMP.
How long does Scalp Micropigmentation last, and does it need touch-ups over time? Providers say SMP usually needs a touch-up every 1 to 5 years. It fades but does not fully disappear, and removal needs laser treatment that may be incomplete.

learn Hair Transplant

Is a hair transplant painful? Clinics say local anaesthetic makes the procedure itself mostly comfortable, but the anaesthetic injections sting and soreness for a few days afterwards is common. Pain varies from person to person.
How much does a hair transplant cost? Hair transplant costs typically range from $1,000 to $25,000 depending on various factors.
Will transplanted hair fall out after a hair transplant? Transplanted hair usually lasts long term, although some grafts may not survive and hair around them can keep thinning. Shedding of the transplanted hairs in the first weeks is normal.

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