22 citations
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September 2008 in “Brain & development” In this study on rats, valproic acid was associated with reduced biotinidase enzyme activity and higher alopecia rates, but biotin supplementation did not significantly affect alopecia occurrence.
15 citations
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May 2006 in “Brain & development” The authors concluded that administering biotin may help prevent alopecia caused by reduced biotinidase activity during valproic acid therapy in rats.
March 2023 in “Mağallaẗ wāsit li-l-ʿulūm wa-al-ṭibb” This case report details a family in Iraq with biotin deficiency, highlighting improved outcomes in surviving children following diagnosis and lifelong biotin supplementation.
September 2009 in “European journal of paediatric neurology” Biotin supplements did not significantly reduce hair loss in rats on valproic acid.
3 citations
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November 2019 in “Clinical psychopharmacology and neuroscience/Clinical Psychopharmacology and Neuroscience” Valproate can cause both hair loss and curly hair in bipolar disorder patients.