53 citations
,
March 2003 in “Journal of Investigative Dermatology”
This study found that human keratinocytes express a sodium-dependent multivitamin transporter for biotin, pantothenic acid, and lipoic acid, including a highly specific biotintransport component.
This case report describes a 10-month-old boy with dermatitis, alopecia, and hypotonia who showed dramatic improvement with oral biotin, suggesting a possible defect in biotin absorption or transport.
In this study, researchers identified genetic variants in the PCCA and PRLR genes that are significantly associated with hair coat length in Brangus heifers, potentially contributing to more thermotolerant cattle.
55 citations
,
November 2019 in “Cellular and Molecular Gastroenterology and Hepatology”
This study found that oral biotin supplementation improved outcomes in a mouse model of inflammatory bowel disease by reducing inflammatory cytokine production and enhancing intestinal barrier integrity, suggesting potential therapeutic benefits for IBD patients.
How much biotin is too much biotin?The NIH Adequate Intake for adults is 30 mcg of biotin a day, and supplements often contain hundreds of times that; no toxic dose has been identified, but the FDA warns that high-dose biotin can distort blood tests including troponin, so tell your doctor and the lab before any test.
A 20-year-old shared their experience of reversing hair loss without using minoxidil or finasteride, instead relying on supplements like biotin, collagen, fish oil, saw palmetto, and various vitamins. They emphasized the importance of a balanced supplement schedule and noted improvements in hair health without experiencing additional shedding.
A 47-year-old male experienced significant hair loss after losing 37 kg in 6 months on a low-carb diet and started taking biotin, zinc, iron, selenium, and spectral dcn-n. Replies suggest that while carbs are not directly needed for hair growth, they help regulate hormones and nutrient absorption, and rapid weight loss can also contribute to hair loss.
The user is concerned about hair shedding despite using topical Minoxidil and oral Finasteride for a year. Others suggest that shedding can be normal, and the treatment may still be effective, advising patience and monitoring.
The user experienced severe hair loss despite using Minoxidil and Finasteride and is considering switching to Dutasteride. Others recommend consulting a dermatologist, checking for health issues, and trying Dutasteride and oral Minoxidil.
A user shared their positive experience with a hair transplant performed by Dr. Bekir Bek in Ankara, involving 3,897 grafts. They stopped using minoxidil and finasteride before the procedure but restarted finasteride afterward and plan to reintroduce minoxidil in a few months.