In this study, researchers engineered extracellular vesicles enriched with functional mitochondria to enhance healing in diabetic wounds by reversing mitochondrial and immunometabolic dysfunction in macrophages.
2 citations
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April 2017 in “Molecular Medicine Reports” In this study, blocking autophagy with 3-methyladenine significantly improved the survival of inner ear hair cells in a gentamicin-induced ototoxic mouse model.
9 citations
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May 2025 in “Stem Cell Research & Therapy” This review discusses how extracellular vesicles play a dual role in age-related diseases by contributing to both disease pathogenesis and potential therapeutic strategies through the transfer of specific molecules.
113 citations
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June 2010 in “Biological Chemistry” This study found that mice deficient in the enzyme cathepsin L exhibited impaired degradation of autophagolysosomal content, leading to an accumulation of large, abnormal vesicles in various tissues.
September 2026 in “Frontiers in Cell and Developmental Biology” This review discusses the role of extracellular vesicles in wound healing, highlighting their impact on macrophage and fibroblast function and the complexity of their effects in different cellular and environmental contexts.