Search

for
Search:

Research

5 / 1000+ results

research A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity

91 citations , May 2005 in “The Journal of Clinical Endocrinology & Metabolism”

In this study, a novel mutation in the glucocorticoid receptor gene was identified in a young woman, impairing glucocorticoid signaling and leading to generalized glucocorticoid resistance.

research In Vitroandin VivoStructure-Activity Relationships of Novel Androgen Receptor Ligands with Multiple Substituents in the B-Ring

20 citations , September 2005 in “Endocrinology”

This study identified novel selective androgen receptor modulators with enhanced in vivo pharmacological activity through structure-activity relationship analysis in castrated rats.

research QSAR Analysis of a Series of Hydantoin‐based Androgen Receptor Modulators and Corresponding Binding Affinities

April 2019 in “Molecular Informatics”

This study employed multiple linear regressions to analyze hydantoin analogues and produced a model with strong predictive abilities for designing new androgen receptor modulators.

research Reactive keratin derivatives: A promising strategy for covalent binding to hair

20 citations , September 2018 in “Journal of colloid and interface science”

This study found that keratin derivatives with functionalized thiol groups improved binding to both natural and bleached hair fibers, suggesting a promising strategy for enhancing keratin's durability in hair repair.

research Synthesis and structure–activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands

18 citations , April 2001 in “Bioorganic & Medicinal Chemistry Letters”

This study identified the N-(iodopropenyl) derivative 13 as a promising candidate for development as a radioiodinated androgen receptor ligand due to its binding affinity.

View more "ar binding affinity" in research →

Community Join

5 / 466 results

community Pyrilutamide ,the molecule’s true nature

in Research 302 upvotes 2 years ago

Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

community Why was fluridil abandoned and never made past phase 2?

5 upvotes 4 years ago

Fluridil was abandoned due to its weak effectiveness and low binding affinity to the androgen receptor, making it less competitive against DHT and testosterone. Users discuss its limited results compared to other treatments like pyrilutamide and RU58841.

community Are Minoxidil & Finasteride/Dutastide the only REAL things that work? Is there anything else I can do for diffuse thinning that actually works on top of these?

13 upvotes 1 year ago

Minoxidil and finasteride are the main effective treatments for hair loss. RU58841 is discussed as a potential option but has concerns about safety and side effects.

community Bile Acid-Mediated DHT Dysregulation Hypothesis

in Research/Science 13 upvotes 1 year ago

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

community Breezula is the final brick in the wall

36 upvotes 2 months ago

Breezula is discussed as a potential topical anti-androgen treatment for hair loss, with mixed opinions on its effectiveness and side effects compared to other treatments like finasteride, minoxidil, and RU58841. Some users express skepticism about its long-term efficacy and potential side effects, while others are hopeful for its approval and use in combination with existing treatments.

View more "ar binding affinity" in community →

Clinics

3 / 3 results

Experts

1 / 4 results

Hair Transplant Surgeon
Dr. Shashikiran AR, MD, MBBS, FRGHS
Mysuru, Karnataka, India

Learn

— no results

Try a deeper search in learn →

Dr. Shashikiran AR, MD, MBBS, FRGHS