278 citations,
March 2013 in “Gut” In this study, 434 patients with inflammatory bowel disease (IBD) treated with anti-TNF-α antibodies were screened for psoriasiform skin lesions, with 21 (4.8%) developing such lesions. Smoking and increased body mass index were identified as significant predictors. Histological analysis revealed infiltrates of Th1 and Th17 cells in the lesions. Nine patients with severe lesions or anti-TNF-induced alopecia were treated with the anti-IL-12/IL-23 antibody ustekinumab, achieving a 100% response rate. The severity of lesions correlated with the number of IL-17A-expressing T cells. The study concluded that anti-IL-12/IL-23 antibody therapy is highly effective for treating these lesions.
January 2019 in “Elsevier eBooks” Scalp psoriasis can cause different types of hair loss, with some patients developing permanent hair loss, and treatment may be stopped due to skin reactions.
39 citations,
April 2016 in “Case Reports in Dermatology” Tofacitinib temporarily regrew hair in a man with alopecia, but its effects didn't last.
1 citations,
April 2018 in “Revista da Sociedade Portuguesa de Dermatologia e Venereologia” Hidradenitis suppurativa is a chronic skin condition more common in women, linked to genetics and lifestyle factors, and associated with various other health issues.
January 2013 in “Open journal of gastroenterology” Ulcerative colitis can cause skin issues due to immune system problems.