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Glossary Antihypertensives

drugs that lower high blood pressure

Antihypertensives, also known as blood pressure medications, are drugs used to treat high blood pressure (hypertension). They work through various mechanisms, such as relaxing blood vessels, reducing blood volume, or decreasing the heart rate, to lower blood pressure and reduce the risk of complications like stroke and heart attack.

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Research

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Spironolactone: An Anti-Androgenic and Anti-Hypertensive Drug That May Provide Protection Against the Novel Coronavirus (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19

research Spironolactone: An Anti-androgenic and Anti-hypertensive Drug That May Provide Protection Against the Novel Coronavirus (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19

36 citations , July 2020 in “Frontiers in Medicine”

Spironolactone might help protect against severe lung problems in COVID-19 patients.

Impact of Low-Dose Oral Minoxidil on Blood Pressure in Androgenetic Alopecia Patients Concomitantly Taking Antihypertensive Medications: A Multi-Center Cohort Study

research 61131 Impact of Low-Dose Oral Minoxidil on Blood Pressure in Androgenetic Alopecia Patients Concomitantly Taking Antihypertensive Medications: A Multi-Center Cohort Study

September 2025 in “Journal of the American Academy of Dermatology”

Low-dose oral minoxidil does not significantly affect blood pressure in patients with hair loss and hypertension.

Low-Dose Oral Minoxidil for Androgenetic Alopecia Is Not Associated With Blood Pressure Changes in Patients Also Taking Other Antihypertensive Medications: A Multi-Center Cohort Study Using TriNetX

research Low-dose oral minoxidil for androgenetic alopecia is not associated with blood pressure changes in patients also taking other antihypertensive medications: A multi-center cohort study using TriNetX

March 2025 in “Journal of the American Academy of Dermatology”

Low-dose oral minoxidil doesn't affect blood pressure in patients taking blood pressure meds.

research Antihypertensive Agents in Dermatology

January 2025

Association of Melanoma and Nonmelanoma Skin Cancer with Antihypertensive Drugs: A Report from the Research on Adverse Drug Events and Reports Project

research Association of melanoma and nonmelanoma skin cancer with antihypertensive drugs: A report from the Research on Adverse Drug events And Reports project

1 citations , April 2016 in “Journal of The American Academy of Dermatology”

Blood pressure medications may increase the risk of skin cancer.

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Community Join

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community Low-Dose Oral Minoxidil Does Not Significantly Affect BP

in Minoxidil 178 upvotes 1 year ago

Low-dose oral minoxidil is used for hair loss and does not significantly affect blood pressure but may increase heart rate and cause hypotensive symptoms. Some users experience side effects like palpitations and shortness of breath, while others find it effective; topical minoxidil with tretinoin is also considered.

community Doctor said minoxidil is "supposed to be only used for 6-9 months"

69 upvotes 1 month ago

A doctor advised stopping minoxidil after a year, suggesting it is typically used for 6-9 months, and prescribed vitamin D, anti-dandruff shampoo, ketoconazole shampoo, and Advantan. Users criticized the doctor's advice, recommending finasteride or dutasteride for long-term hair loss treatment.

community Thoughts about ORAL ketoconazole? (pills)

8 months ago

Oral ketoconazole is discussed as a potential hair loss treatment, but it poses significant health risks like liver damage and adrenal insufficiency. Users suggest safer alternatives like topical anti-androgens or spironolactone, emphasizing the importance of consulting a specialist.

community Finasteride's impact on blood pressure - mechanism of action

4 upvotes 5 years ago

Finasteride may cause mild blood pressure-related side effects in less than 10% of users, unlike minoxidil, which has stronger effects. Alternatives like topical ketoconazole and dermarollers are suggested for those concerned about finasteride's side effects.

community 3.5 months minoxidil , 2.5 months 1mg fin update ( also 22 kg weight loss in 6 months! )

10 upvotes 4 years ago

A 21-year-old experienced hair regrowth and improved health after using topical minoxidil, finasteride, and zinc shampoo, alongside lifestyle changes like weight loss and exercise. They also started microneedling and managed seborrheic dermatitis with benzoyl peroxide mixed in shampoo.

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Learn

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learn Minoxidil

An essential vasodilator with some anti-androgenic effects

learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

learn Procyanidin

bioflavonoid found in plants with antioxidant and hair stimulating properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Overview

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is a topical anti-androgen that degrades androgen receptors to combat hair loss.

learn Aminexil

Aminexil: Can I combine it with anti-hair loss shampoos or will it lose effectiveness? You can safely combine Aminexil with anti-hair loss shampoos for enhanced effectiveness.

learn Cetirizine

What makes cetirizine a unique anti-inflammatory option for your scalp? Laboratory work reports that cetirizine lowers PGD2 and other inflammatory mediators, which is why researchers have proposed it for the scalp. There is no approved topical product and the clinical evidence is one small unblinded pilot study in pattern hair loss, so scalp use is off-label and experimental.

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Clinics

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All 77 clinic results →

Experts

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16
Dermatologist
Andi Iryanti, M. Biomed
Indonesia

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Andi Iryanti, M. Biomed