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Glossary Androstenedione

steroid hormone precursor to testosterone and estrogen

Androstenedione, often referred to as Andro, is a steroid hormone that serves as a precursor in the biosynthesis of testosterone and estrogen. It is produced in the adrenal glands, ovaries, and testes, and plays a crucial role in the development of secondary sexual characteristics and reproductive function. Elevated levels of androstenedione can be associated with conditions like polycystic ovary syndrome (PCOS) and certain forms of adrenal hyperplasia.

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research Puberty in Boys: Correlation of Plasma Levels of Gonadotropins (LH, FSH), Androgens (Testosterone, Androstenedione, Dehydroepiandrosterone and Its Sulfate), Estrogens (Estrone and Estradiol) and Progestins (Progesterone and 17-Hydroxyprogesterone)

96 citations , September 1975 in “The Journal of Clinical Endocrinology & Metabolism”

In this study, significant elevations of DHA and testosterone were associated with pubic hair development and voice changes in boys during puberty.

research Elevated serum androstenedione is associated with a more severe phenotype in women with polycystic ovary syndrome (PCOS)

28 citations , April 2014 in “Hormones”

This study found that increased serum A4A levels were associated with more severe polycystic ovary syndrome phenotypes and could be a useful marker for biochemical hyperandrogenemia.

The Influence of Obesity on Androstenedione to Testosterone Ratio in Women with Polycystic Ovary Syndrome and Hyperandrogenemia

research The influence of obesity on Androstenedione to Testosterone ratio in women with polycystic ovary syndrome (PCOS) and hyperandrogenemia

15 citations , October 2011 in “Gynecological Endocrinology”

This study found that obesity in PCOS women with biochemical hyperandrogenemia lowers androstenedione levels and increases the testosterone to androstenedione ratio, but this was not observed in women with clinical hyperandrogenemia or in controls.

research Scalp hair 17‐hydroxyprogesterone and androstenedione as a long‐term therapy monitoring tool in congenital adrenal hyperplasia

9 citations , April 2016 in “Clinical Endocrinology”

This study suggests that measuring scalp hair 17-hydroxyprogesterone and androstenedione concentrations can be a promising tool for monitoring treatment in children with congenital adrenal hyperplasia.