57 citations
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April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that despite the presence of steroidogenesis inhibitors, CRPC tumor cells adapt to continue synthesizing androgens, suggesting a need for more effective androgen axis targeting.
2 citations
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June 2022 in “대한스포츠의학회지” This article reviews the development of selective androgen receptor modulators and myostatin inhibitors as performance-enhancing drugs, highlighting ongoing challenges in achieving truly tissue-selective anabolic agents and reporting no new experimental findings.
January 2014 in “edoc (University of Basel)” This research suggests that fluoxymesterone, an anabolic steroid, may inhibit a key enzyme, potentially contributing to cardiovascular issues by affecting cortisol's activation of mineralocorticoid receptors.
5 citations
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January 2005 in “Journal of Enzyme Inhibition and Medicinal Chemistry” This study found that certain steroidal compounds, especially 10a–10c, demonstrated strong antiandrogenic activity by binding to the androgen receptor and reducing prostate weight in a hamster model.
January 2026 in “Neurochemistry International” This study reports that in human glioblastoma and neuroblastoma cell lines, 24-hydroxycholesterol significantly suppressed the conversion of testosterone to growth-inducing androgens via the 5α-reductase pathway, revealing a new connection between cholesterol homeostasis and androgen metabolism.