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research Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut

2 citations , July 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that oral administration of Thauera sp. strain GDN1 reduced serum androgen levels in male mice by about 50%, suggesting its potential as a probiotic treatment for hyperandrogenism.

research Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut

37 citations , February 2023 in “Gut Microbes”

This study found that administering the gut bacterium Thauera sp. strain GDN1 to mice significantly reduced their serum androgen levels, indicating gut bacteria may influence androgen metabolism.

research Steroid 5α-reductases and 3α-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism

115 citations , March 2001 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

This article reviews how different 5alpha-reductase and 3alpha-HSD enzymes impact androgen levels and highlights their potential as drug targets for androgen-related diseases, but provides no new experimental findings.

research Steroidogenesis of the testis – new genes and pathways

70 citations , April 2014 in “Annales d'endocrinologie”

This review discusses the pathways of androgen biosynthesis and reports no new findings, highlighting the need to understand the interplay between the classic and backdoor pathways.

research Gene expression of type 2 17β hydroxysteroid dehydrogenase in scalp hairs of hirsute women

28 citations , August 2003 in “Steroids”

This study found that untreated hirsute patients have lower expression of type 2 17β-HSD mRNA in scalp hairs, indicating potential disturbances in androgen metabolism, compared to treated hirsute patients.

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community My Idea for a possible new hairloss treatment

53 upvotes 6 years ago

Exploring a potential hair loss treatment using the enzyme AKR1C2 to locally reduce DHT levels. Challenges include enzyme delivery through the skin and high production costs, with gene therapy or stem cells suggested as future alternatives.

community How to know if shedding is from tren or minoxidil?

in Minoxidil 5 upvotes 2 years ago

The user started using trenbolone and minoxidil simultaneously and experienced increased hair shedding, unsure which is causing it. Replies suggest both drugs could cause hair loss, with one advising to stop trenbolone to protect hair and another indicating minoxidil is unlikely the cause due to the timing.

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Hair System Specialist
Jane Genesi
Marlton, PA, United States

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Jane Genesi