Circulating Androgen Regulation by Androgen-Catabolizing Gut Bacteria in Male Mouse Gut

    July 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Tsun‐Hsien Hsiao, Chia-Hong Chou, Yi‐Lung Chen, Po‐Hsiang Wang, Guo-Jie Brandon-Mong, Tzong‐Huei Lee, Tien-Yu Wu, Po-Ting Li, Chenwei Li, Yi-Li Lai, Yu-Lin Tseng, Chao-Jen Shih, Mei‐Jou Chen, Yin‐Ru Chiang
    TLDR Certain gut bacteria can lower androgen levels in male mice.
    The study investigated the role of Thauera sp. strain GDN1, a betaproteobacterium, in regulating androgen levels in male mice. By administering this strain to C57BL/6J mice, researchers observed a significant reduction of approximately 50% in serum androgen levels. The study revealed that these bacteria could catabolize androgens aerobically and anaerobically in the gut, using them as a carbon source. This process was confirmed through genetic and biochemical analyses, which showed differential expression of androgen catabolic genes in the ileum and caecum. The findings suggested the potential of using androgen-catabolizing bacteria like Thauera sp. strain GDN1 as probiotics to treat conditions associated with high androgen levels, such as hyperandrogenism.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community How to know if shedding is from tren or minoxidil?

      in Minoxidil  5 upvotes 1 year ago
      The user started using trenbolone and minoxidil simultaneously and experienced increased hair shedding, unsure which is causing it. Replies suggest both drugs could cause hair loss, with one advising to stop trenbolone to protect hair and another indicating minoxidil is unlikely the cause due to the timing.

      community FDA approves Cassiopea's WINLEVI (CB-03-01, 1% formulation) for Acne

      in Technology  34 upvotes 5 years ago
      The conversation is about the FDA approval of WINLEVI for acne treatment and the anticipation of Breezula, a hair loss treatment using the same active ingredient, which may indicate a positive future for Breezula's release. There is disappointment that Breezula's results are not optimal, but it is seen as progress in hair loss treatment.

      community 10 months CB and Oral Minoxidil

      in Progress Pictures  112 upvotes 1 year ago
      A person with Alopecia Areata on their beard is using CB-03-01 and oral minoxidil for treatment. Some users question the effectiveness of CB-03-01 for beard hair, suggesting that minoxidil alone may be responsible for any observed hair growth.

      community HairClone to start hair multiplication services in 2022

      in Update  135 upvotes 4 years ago
      HairClone plans to start hair multiplication services in 2022. Users discuss various treatments like Minoxidil, finasteride, PRP, and hair cloning, expressing both hope and skepticism about the technology and its costs.

    Similar Research

    5 / 1000+ results