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research Human Skin is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1)

289 citations , May 2003 in “Journal of Investigative Dermatology”

This study demonstrates that human skin is capable of steroid hormone synthesis, but its role in androgenic skin disorders like acne and alopecia is yet to be clarified.

research Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation

195 citations , November 2001 in “The Journal of Cell Biology”

This study found that desmocollin 1 is crucial for strong adhesion and barrier maintenance in the mouse epidermis, with its absence leading to skin and hair issues resembling chronic dermatitis.

research PUVA treatment of alopecia areata partialis, totalis and universalis: audit of 10 years' experience at St John's Institute of Dermatology

105 citations , December 1995 in “British journal of dermatology/British journal of dermatology, Supplement”

This retrospective study concluded that PUVA treatment is generally ineffective for alopecia areata, with low effective success rates for partialis, totalis, and universalis types.

research In Human Skin, UVB Initiates Early Induction of IL-10 Over IL-12 Preferentially in the Expanding Dermal Monocytic/Macrophagic Population

101 citations , July 1998 in “Journal of Investigative Dermatology”

This study found that UV exposure in human skin induces IL-10 production by macrophages, while Langerhans cells are depleted and their IL-12 production is downregulated.

research Immunohistochemical localization of types 1 and 2 5α-reductase in human scalp

100 citations , September 1999 in “British Journal of Dermatology”

This study suggests that finasteride's effect on promoting hair growth in men with androgenetic alopecia may be due to its inhibition of 5aR2 localized in hair follicles.

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community Does 10-14 days off fin ruin progress - evaluating fog and every day, EOD, topical

5 upvotes 6 days ago

Taking a 10-14 day break from finasteride likely won't ruin hair progress, and switching to every other day or topical application could be alternatives if brain fog persists. Users shared experiences of taking breaks without noticeable hair loss.

community (22m) 10 month 1mg Finastride results.

6 upvotes 2 weeks ago

The user is not satisfied with the results after 10 months of using finasteride and plans to start using topical minoxidil for hair regrowth. Other users suggest considering oral minoxidil, microneedling, and possibly switching to dutasteride for better results.

community Almost 10 months into dut/oral min and it’s getting worse (with pics)

132 upvotes 1 month ago

A user switched from finasteride and topical minoxidil to dutasteride and oral minoxidil, but experienced worsening hair loss and thinning. Suggestions included returning to finasteride, adding finasteride to the current regimen, or considering other factors like genetics or additional causes of hair loss.

community 10 month progress. I feel stalled at the very least.

in Progress Pictures 26 upvotes 2 months ago

The user has been using 1.2 mg Finasteride and 3 mg Minoxidil orally for 10 months, initially seeing progress but now feeling stalled. Suggestions include adding microneedling, Ketoconazole shampoo, or considering a hair transplant.

community (M25) 10 months on oral min/fin, no growth. Need advice

in General 43 upvotes 4 months ago

The user has been taking oral minoxidil and finasteride for 10 months with no hair growth but no further hair loss. They are considering adding rosemary oil and possibly returning to a topical solution.

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Learn

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learn Polyquaternium-10

learn TDM-105795

What is TDM-105795, and why is it being studied as a potential product for hair loss and hair growth support? TDM-105795 is an experimental topical drug that has been tested only in men with androgenetic alopecia, in two Phase 1 studies and one 16-week Phase 2 trial of 71 men. It is not approved, and no peer-reviewed trial results have been published.
How is TDM-105795 used in hair-related products, and is it being explored as a topical treatment, an oral option, or both? TDM-105795 is not sold in any hair product — it is an unapproved experimental compound. The public trial registry shows it has been studied only as a topical scalp solution, in three completed company trials (the largest a 71-participant, 16-week Phase 2); no oral programme is registered, and no peer-reviewed publication exists.
What types of alopecia or hair loss conditions might TDM-105795 be designed to target based on current research? TDM-105795 has been studied only in men with androgenetic alopecia, in two Phase 1 studies and one 16-week Phase 2 trial. There is no research on it in women or in any other type of hair loss.
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