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research Combination of All-Trans Retinoic Acid Resumes the Sustained Response of TPO-RA in ITP

November 2024 in “Blood”

This study found that a short-term treatment with all-trans retinoic acid may effectively stabilize platelet counts in idiopathic thrombocytopenic purpura patients experiencing fluctuations during thrombopoietin receptor agonist therapy.

research lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions

4 citations , August 2022 in “Cells”

This study found that the lncRNA lncRNA2919 is involved in hair follicle regeneration by downregulating growth-related genes, inhibiting cell proliferation, and promoting apoptosis in rabbit dermal papilla cells.

research Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors, cyclosporin A, FK506, ascomycin and rapamycin, on hair growth initiation in mouse: immunosuppression is not required for new hair growth

20 citations , January 1995 in “Journal of Dermatological Science”

This study found that topical application of cyclosporin A and FK506 induces new hair growth in mice, while ascomycin and rapamycin do not, suggesting hair induction is not due to immunosuppression.

research Trans-Epidermal Elimination Due to Insulin Formulation: Report of a Rare Adverse Effect

July 2025 in “Indian Dermatology Online Journal”

In this case report, researchers documented a rare instance of trans-epidermal elimination of insulin formulation in a 45-year-old woman with diabetes, suggesting that insulin or its excipients may have caused a granulomatous reaction leading to skin lesions at injection sites and impaired diabetes control.

research [Local therapy of androgenetic alopecia with 17 alpha-estradiol. A controlled, randomized double-blind study (author’s transl)].

37 citations , January 1980 in “PubMed”

This study found that topical hair lotions with 17 alpha-estradiol may reduce telogen hair loss in patients with androgenetic alopecia, though they did not lead to new hair regrowth.

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Community Join

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community Trans guy with frontal hair loss - making sure I'm doing the right things.

5 upvotes 8 years ago

A trans man experiencing frontal hair loss is considering using finasteride and minoxidil, while also consulting a dermatologist. He is cautious about starting treatments before his appointment and is concerned about the effects of rapid weight loss on his hair.

community Testosterone in Reference Range Doesn't Cause Hair Loss

52 upvotes 2 years ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community Hair Loss Drugs Ranked in Order of Efficacy

in Research/Science 67 upvotes 2 years ago

Dutasteride is likely the most effective treatment for male pattern baldness, followed by finasteride and minoxidil in various forms and dosages. Users discuss personal experiences, dosages, and potential side effects, with some considering combining treatments for better results.

community Ray Peat: Testosterone Isn’t the Culprit, Prolactin and Cortisol Drive Hair Loss (2016)

in Research/Science 110 upvotes 11 months ago

Prolactin and cortisol are identified as key factors in hair loss, with stress hormones impacting hair shedding. Finasteride and minoxidil are effective treatments, while DHT's role and individual sensitivity are significant factors.

community Common hair-loss drug consistently associated with higher rates of psychiatric harm

in Research/Science 183 upvotes 11 months ago

Finasteride and dutasteride can cause psychiatric side effects like depression and suicidal thoughts in some users, especially those with a history of mental health issues. While some users experience positive hair growth results, others face severe psychological effects, raising concerns about their safety and the need for careful monitoring.

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Learn

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learn Hair Transplant

Can a hair transplant be done without shaving? Yes, hair transplants can be done without shaving, but eligibility varies.
How long does it take for transplanted hair to grow after a hair transplant? New hair growth after a transplant typically starts around 3-4 months.
Do hair transplants look natural? Clinics say a well-done transplant can look natural, but results vary with the surgeon, your hair and donor supply, and scars can show with very short hair.

learn Alfatradiol

Does Alfatradiol work the same for women, men, and trans people? Almost all controlled data on topical alfatradiol comes from cisgender women, where hair density and thickness stayed nearly unchanged over 6 months while minoxidil improved them (the trial had no placebo group). No published controlled trial covers cisgender men, and none covers trans people at all — so the honest answer is that the difference has not been measured.

learn Tretinoin

Vitamin A retinoid cream, prescribed for acne

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