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Long-Term Dutasteride Therapy in Men with Benign Prostatic Hyperplasia Alters Glucose and Lipid Profiles and Increases Severity of Erectile Dysfunction

research Long-Term Dutasteride Therapy in Men with Benign Prostatic Hyperplasia Alters Glucose and Lipid Profiles and Increases Severity of Erectile Dysfunction

20 citations, June 2017 in “Hormone Molecular Biology and Clinical Investigation”

Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

research Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men

31 citations, January 2017 in “Advances in Experimental Medicine and Biology”

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

research Targeting the Pre-Receptor Metabolism of Cortisol as a Novel Therapy in Obesity and Diabetes

70 citations, March 2010 in “The Journal of Steroid Biochemistry and Molecular Biology”

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

research Frontal Fibrosing Alopecia: A Review of Disease Pathogenesis

2 citations, July 2022 in “Frontiers in Medicine”

The cause of Frontal fibrosing alopecia, a type of hair loss, is complex, likely involving immune responses and genetics, but is not fully understood.

research Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair

124 citations, June 2020 in “Cell Stem Cell”

Fat cells in the skin help start healing and form important repair cells after injury.

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community Efficacy of different dutasteride doses vs finasteride

in Research/Science 123 upvotes 1 year ago

Dutasteride doses matter for hair loss treatment and are more effective than finasteride. RU58841 is suggested for better gains, but side effect profiles should be considered.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 2 months ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 82 upvotes 5 months ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

community Increased adipose tissue (being overweight) in males may increase likelyhood of finasterde side effects

in Research/Science 30 upvotes 3 months ago

Being overweight may increase finasteride side effects due to higher aromatase activity converting testosterone to estradiol. Maintaining a healthy weight could reduce these side effects.

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