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research Age-Dependent Loss of the Stemness and Antimicrobial Defense Function of Dermal Fibroblasts Is Mediated by TGFbeta

April 2018 in “Journal of Investigative Dermatology”

Aging reduces skin cell renewal and defense against germs due to TGFbeta, but blocking TGFbeta could help restore these functions.

research Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta

96 citations, December 2018 in “Immunity”

Targeting TGFβ can improve skin immunity in older people.

research Effect of Ginsenoside Rd on Dermal-Epidermal Junction in Fibroblast

April 2018 in “Journal of Investigative Dermatology”

Ginsenoside Rd may help improve skin aging by increasing collagen in the skin.

research Molecular Profiling of Frontal Fibrosing Alopecia Reveals TH1 and JAK-STAT Up-Regulation with No Suppression of Hair Keratins

2 citations, April 2018 in “Journal of Investigative Dermatology”

Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.

research Impairment of Hair-Inducing Capacity of 3D-Cultured Human Dermal Papilla Cells by the Ablation of STAT5

April 2018 in “Journal of Investigative Dermatology”

Removing STAT5 from 3D-cultured human skin cells reduces their ability to grow hair.

View more "adipogenic-antimicrobial function" in research →

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community The Big Fat Layer / Remedies: Cetirizine

in Treatment 10 upvotes 3 years ago

Treating hair loss with various remedies, such as Cetirizine and the Big3 complex (minoxidil, finasteride, and RU58841), which have properties like adipogenic, anti-fibrotic and anti-inflammatory. References to research studies are also included.

community The Big Fat Layer II

in Research/Science 26 upvotes 3 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

community i hate how much i’m stressing about hair loss

in Chat 78 upvotes 1 year ago

Someone who is starting to experience hair loss and is considering multiple treatments, such as minoxidil, finasteride, dutasteride, and a hair transplant, to manage it. Replies provide advice on how to approach these treatments safely and effectively.

community Stop expecting results in 2 months!

in Treatment 125 upvotes 7 months ago

People discussing hair loss treatments emphasize the need for patience, as results from using finasteride and minoxidil can take 8-12 months or longer. Some users report early signs of improvement, while others experience continued shedding or slower progress.