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Aging reduces skin cell renewal and defense against germs due to TGFbeta, but blocking TGFbeta could help restore these functions.

Targeting TGFβ can improve skin immunity in older people.

Ginsenoside Rd may help improve skin aging by increasing collagen in the skin.

Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.

Removing STAT5 from 3D-cultured human skin cells reduces their ability to grow hair.

Kaempferol helps skin stem cells grow and may improve skin thickness due to its 3-OH group.

Obesity can weaken the skin's ability to fight infections because fat cells stop and reduce the infection-fighting properties of nearby stem cells.

DNMT3A is crucial for healthy skin and hair growth.

Activating Wnt in skin cells controls the number of hair follicles by directing cell movement and fate.

Arrector pili muscle regulates hair follicle stem cells, DNA methylation needed for hair cycling, and Wnt/B-catenin signaling starts hair growth.

Skin fat plays a key role in immune defense and healing beyond just storing energy.

Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.

Skin aging is a complex process influenced by various factors, leading to wrinkles and sagging, and should be considered a disease due to its health impacts.

Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.

Aging slows wound healing due to weaker cells and immune response.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Fat cells in the skin help start healing and form important repair cells after injury.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

TGFβ signaling prevents sebaceous gland cells from producing fats.

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

Pumpkin seeds may improve health due to their rich nutrients and potential to treat various conditions.

Skin fat helps with body temperature control and has other active roles in health.

Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

Eclipta alba extract may help treat obesity by blocking fat cell formation and lowering blood lipid levels.

The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.

Fat cells are important for tissue repair and stem cell support in various body parts.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.