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research Traditional Uses and Pharmacologically Active Constituents of Dendrobium Plants for Dermatological Disorders: A Review

65 citations , April 2021 in “Natural Products and Bioprospecting”

This review discusses the traditional uses and pharmacologically active compounds of 22 Dendrobium species for dermatological disorders but reports no new results, highlighting the need for further research.

research Applications of Tea (Camellia sinensis) and its Active Constituents in Cosmetics

67 citations , November 2019 in “Molecules”

This review collected findings on the various cosmetic and therapeutic properties of tea extracts, highlighting their antioxidant, anti-inflammatory, and photoprotective effects among other benefits for skin and hair care.

research Mechanism of action of herbs and their active constituents used in hair loss treatment

47 citations , August 2016 in “Fitoterapia”

This article reviews mechanisms by which herbal ingredients may stimulate or inhibit hair growth, and it reports no new clinical findings while suggesting potential for developing hair loss treatments.

research Testosterone 5.ALPHA.-Reductase Inhibitory Active Constituents of Piper nigrum Leaf

44 citations , January 2007 in “Biological & pharmaceutical bulletin”

This study found that Piper nigrum leaf extract showed in vivo anti-androgenic activity and potent 5α-reductase inhibitory effects, with piperine and (−)-cubebin identified as active components.

research Anti-androgenic Activity of Myricae Cortex. Isolation of Active Constituents from Bark of Myrica rubra.

51 citations , January 2001 in “Biological & Pharmaceutical Bulletin”

This study found that the aqueous ethanol extract of Myricae Cortex demonstrated in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic effects in mouse and hamster models.

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community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

community Evidence-based natural treatment that works for me

3 years ago

A user shared a natural hair loss treatment involving micro-needling and a mix of turmeric, cinnamon, and coconut oil, claiming it effectively thickened their hair. The treatment is applied every two to three weeks, but some users expressed skepticism and requested photographic evidence.

community PP405 Identity Research

in Research 292 upvotes 1 year ago

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

community Surprisingly thorough study on He-Shou-Wu/Fo Ti

13 upvotes 3 years ago

He Shou Wu (Fo Ti) extract was found to prolong the hair growth phase, inhibit 5-alpha-reductase (like finasteride), reduce androgen receptors, and increase growth factors, potentially outperforming minoxidil in recovering hair follicle size after DHT exposure. Two compounds, emodin and TSG, are identified as responsible for these effects and warrant further investigation.

community Any active Kx-826 Pyrilutamide group buys happening?

10 upvotes 4 years ago

The conversation discusses organizing group buys and tracking progress for Kx-826 Pyrilutamide, a hair loss treatment. Participants express optimism about upcoming results and concerns about self-reporting bias.

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learn Beta Polypeptide

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Glycerin

Can glycerin be used in combination with active ingredients like minoxidil or tretinoin? Glycerin is a common humectant that formulators treat as compatible with topical actives, but no published trial has tested it alongside minoxidil or tretinoin, so any benefit is comfort rather than a proven effect. Tretinoin is prescription-only and carries pregnancy warnings.

learn Pyrithione Zinc

Can pyrithione zinc be combined with other active ingredients like ketoconazole or minoxidil? Pyrithione zinc can be safely combined with ketoconazole and minoxidil.

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