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research Synthesis of Analogues of Cercidin, an Antimicrobial Compound of Cercidiphyllum japonicum : Glycosylation of Methyl Gallate with Ulosyl Bromides

June 2025 in “Natural Product Communications”

This study successfully synthesized novel cercidin analogues from Cercidophyllum japonicum, confirming their structure via NMR data. The researchers suggest these compounds could facilitate future antibiotic development by advancing structure-activity-relationship studies.

research Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships

204 citations , February 2000 in “Current Medicinal Chemistry”

This review discusses the use of antiandrogens like flutamide and its derivatives in prostate cancer treatment and highlights the need for next-generation antiandrogens for improved efficacy; it reports no new clinical results.

research Androgen antagonists in androgen target tissues

27 citations , January 1984 in “Pharmacology & Therapeutics”

This review discusses androgen manipulation strategies for conditions like benign prostatic hyperplasia and prostatic carcinoma but reports no new clinical results.

research Synthesis of Spiro[cyclohexane-1,2?-[2H]indene] derivatives as inhibitors of steroid 5?-reductase

8 citations , June 1995 in “Helvetica Chimica Acta”

This article outlines the synthesis of spiro[cyclohexane‐1,2′‐[2 H ]indene] derivatives similar to known steroid 5α‐reductase inhibitors, but it does not report experimental findings.

research The First Syntheses of 16β-Chloro- and 16β-Bromo-cyproterone Acetate

3 citations , January 2003 in “Synthetic Communications”

This research describes the synthesis of 16β-chloro- and 16β-bromo-cyproterone acetate, detailing the chemical processes involved, but reports no clinical outcomes.

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community 2% Ketoconazole/Nizoral Daily?

in Ketoconazole 11 upvotes 10 months ago

Using 2% ketoconazole daily can dry out the scalp; 1-2 times a week is recommended. Combining ketoconazole with treatments like minoxidil, alfatradiol, and fluridil can help manage hair loss effectively.

community Has anyone else had much worse hair from excessive use of Nizoral?

in Ketoconazole 19 upvotes 1 year ago

Excessive use of Nizoral can lead to dry, brittle hair and is not recommended more than 1-2 times a week. Users suggest using conditioner to mitigate dryness and note that Nizoral is more effective for treating fungal issues rather than regrowing hair.

community Completely obliterated my diffuse thinning without Finasteride w/ pictures

in Journals / Progress Pictures 205 upvotes 1 year ago

The user improved diffuse thinning without finasteride by using minoxidil foam, cold showers, gentle hair drying, 2% ketoconazole, sulfate-free tea tree oil shampoo, dermastamping, and supplements like Omega-3, Vitamin-D, Biotin, Keratin, Collagen, B3, Zinc, and Magnesium. The regimen was followed for about six months under dermatologist guidance.

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