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Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride

research Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride

25 citations , September 1998 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

research 5-Alpha-Reductase Inhibitors and Combination Therapy

15 citations , July 2016 in “Urologic Clinics of North America”

Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.

research Metabolic Dysfunction in Female Mice with Disruption of 5α-Reductase 1

11 citations , January 2017 in “Journal of Endocrinology/Journal of endocrinology”

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for Screening Steroid 5-Alpha Reductase in Human and Fish Cell Lines

research Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for Screening Steroid 5-Alpha Reductase in Human and Fish Cell Lines

3 citations , February 2021 in “Molecules”

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

research Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition

98 citations , April 1997 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

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Community Join

5 / 40 results

community Ultimate Non-5AR (fin/dut) stack?

in Treatment 1 upvotes 5 months ago

The conversation discusses alternatives to 5AR inhibitors for hair loss treatment, suggesting options like minoxidil, KX-826, pyrilutimide, microneedling, and topical bicalutamide. Concerns about side effects and the effectiveness of these treatments are also highlighted.

community Pyrilutamide for non-5AR users?

in Treatment 11 upvotes 9 months ago

Pyrilutamide is considered by some as an alternative for those avoiding 5AR inhibitors like finasteride and dutasteride, but opinions on its effectiveness vary. Some users report similar results with fluridil and pyrilutamide, while others find pyrilutamide less effective compared to prescription treatments.

community 1 year of .5mg oral dut, .3% topical fin and 6% topical min everyday

in Finasteride/Dutasteride 88 upvotes 1 month ago

A 25-year-old is experiencing hair thinning despite using 0.5mg oral dutasteride, 0.3% topical finasteride, and 6% topical minoxidil daily for a year. They are considering increasing dutasteride dosage and exploring other treatments like microneedling and KX 826, while seeking further medical opinions on their condition.

community How come beard hair on minoxidil is permanent while scalp hair while on it under fin/duta is not?

in Minoxidil 50 upvotes 7 months ago

Beard hair grown with minoxidil can become permanent because it is not sensitive to DHT, unlike scalp hair, which requires ongoing minoxidil use even with DHT blockers like finasteride or dutasteride. Dutasteride reduces scalp DHT significantly but not completely, which may explain why scalp hair still needs minoxidil for maintenance.

community Brutal shed at 5 months

in Minoxidil 7 upvotes 4 years ago

User experienced significant hair regrowth with multiple treatments, but then had a brutal shedding period, losing progress. Others questioned the number of treatments used and potential side effects.

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