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Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride

research Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride

25 citations, September 1998 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

research 5-Alpha-Reductase Inhibitors and Combination Therapy

15 citations, July 2016 in “Urologic Clinics of North America”

Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.

research Metabolic Dysfunction in Female Mice with Disruption of 5α-Reductase 1

11 citations, January 2017 in “Journal of Endocrinology/Journal of endocrinology”

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for Screening Steroid 5-Alpha Reductase in Human and Fish Cell Lines

research Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for Screening Steroid 5-Alpha Reductase in Human and Fish Cell Lines

3 citations, February 2021 in “Molecules”

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

research Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition

98 citations, April 1997 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

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Community Join

5 / 21 results

community Brutal shed at 5 months

in Minoxidil 6 upvotes 3 years ago

User experienced significant hair regrowth with multiple treatments, but then had a brutal shedding period, losing progress. Others questioned the number of treatments used and potential side effects.

community Any news on potential hair loss treatments?

in Research/Science 12 upvotes 9 months ago

The conversation is about seeking updates on new hair loss treatments, specifically mentioning scube3 and GT20029, with one person mentioning HMI_115 as showing promising results.

community Ingest topical minoxidil by mouth ?

in Minoxidil 6 upvotes 2 years ago

A user questions if ingesting topical minoxidil could be an alternative to oral minoxidil for hair loss. Another user reports success with this method, noting they saw results and experienced no adverse effects.

community Can dut save my temples? I've been on fin for 2 years but im plateauing

in Progress Pictures 132 upvotes 1 month ago

OP is considering adding dutasteride to their regimen of finasteride and minoxidil to address hair loss plateauing. Users suggest oral minoxidil, microneedling, and possibly a hair transplant, with mixed opinions on dutasteride's effectiveness for temple regrowth.

community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI

in Finasteride/Dutasteride 26 upvotes 2 months ago

The conversation discusses the effectiveness and skepticism around topical dutasteride for hair loss, with mentions of combining it with other treatments like minoxidil and oral medications. Some users doubt its efficacy due to lack of independent studies and potential conflicts of interest.

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