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    Did you mean 5-alpha-reductase inhibition?
    Glossary5α-reductase inhibition

    blocking enzyme that converts testosterone to hair-loss hormone DHT

    5α-reductase inhibition refers to the process of blocking the enzyme 5α-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). DHT is a hormone that can contribute to hair loss and conditions like benign prostatic hyperplasia. By inhibiting this enzyme, medications like finasteride and dutasteride can help reduce hair loss and treat these conditions.

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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 3 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Tressless users finding the Scroll of Truth

      in Satire  132 upvotes 2 weeks ago
      The conversation humorously discusses hair loss treatments, focusing on the use of finasteride and dutasteride, with some users debating the effectiveness and cost of different dosages. Some users mention using topical minoxidil and express concerns about side effects and availability of higher doses.

      community Why does it seem everyone favors finasteride over dutasteride?

      in Female  62 upvotes 7 months ago
      The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.