Search

for
Search:

Research

5 / 1000+ results

research 5α-Reductases in Human Physiology: An Unfolding Story

November 2012 in “Endocrine Practice”

This review outlines the physiological roles of 5a-reductases and highlights the need for further research to better understand their function and minimize adverse effects from their inhibitors used in treatment.

research The influence of low dose finasteride, a type II 5α-reductase inhibitor, on circulating neuroactive steroids

2 citations , September 2009 in “Hormone Molecular Biology and Clinical Investigation”

This study found that low-dose finasteride treatment in men with premature androgenetic alopecia decreased levels of 5α-reduced steroids, which may be linked to increased depression symptoms.

research Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites

18 citations , March 2020 in “Frontiers in Neuroendocrinology”

This study suggests that synthetic steroid analogues or 5α-reductase modulation could be potential therapeutic strategies for nervous system disorders, but further research on their effects is necessary.

research Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition

37 citations , September 2018 in “Psychoneuroendocrinology”

This study found that finasteride treatment in male rats led to enduring effects on depressive-like behavior, hippocampal neurogenesis and neuroinflammation, and gut microbiota composition after withdrawal.

research Early postnatal neuroactive steroid manipulation differentially affects recognition memory and passive avoidance performance in male rats

2 citations , July 2020 in “Behavioural Brain Research”

This study found that neonatal administration of finasteride affected adult learning and memory in rats, enhancing object recognition but impairing aversive learning, with no effect on anxiety-like behavior.

View more "5a-reduced neuroactive steroids" in research →

Community Join

3 / 120 results

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community Doctor says i shouldn't take fin because its "hormonal"

102 upvotes 2 years ago

A user in Turkey was advised by a dermatologist to avoid finasteride due to its hormonal effects and was prescribed minoxidil, shampoo, and vitamins instead. The user is considering seeking another doctor's opinion or buying finasteride directly from a pharmacy.

community Supposedly dairy contains precursors to DHT that are already 5a-reduced and convert to DHT independent of 5a-reductase inhibition

26 upvotes 5 months ago

Dairy may contain DHT precursors that could affect hair loss and prostate health, with some users noting reduced hair shedding after eliminating dairy. Individual responses to dairy and DHT blockers vary, with some attributing hair health to diet changes and others seeing no impact.

View more "5a-reduced neuroactive steroids" in community →

Experts

2 / 2 results

Clinics