research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases
This review discusses the biochemical properties and clinical significance of 5 alpha-reductase isozymes and reports no new clinical results.
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5 / 1000+ results research FRI-02 FROM GIRLS TO BOYS TO OLDER MEN, THE INTERESTING TALE OF THE GUEVEDOCES AND 5-ALPHA REDUCTASE INHIBITORS
This historical review traces the discovery of 5-alpha reductase inhibitors, widely used in urology, from the study of guevedoces, Dominican children with a rare disorder leading to significant androgenization at puberty.
research Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors
This study found that male 5α-reductase 2 knockout mice showed deficits in social dominance behaviors and reduced dopamine receptor binding in a brain region related to social ranking.
research Structure of human type II 5 alpha-reductase gene
This study details the isolation and characterization of the human type II 5 alpha-reductase gene, which may play a role in male pseudohermaphroditism, prostate cancer, and benign prostatic hyperplasia.
research Fast Motions in 5 Alpha Reductase and Its Impact on Enzyme Kinetics
In this study, researchers using QM/MM simulations identified key molecular motions and residue interactions in the enzyme SRD5A2 that significantly influence its catalytic efficiency, demonstrating that specific residues play critical roles in stabilizing transition states and reducing activation barriers.
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5 / 1000+ resultscommunity 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001).
Sugary beverages increase the risk of pattern hair loss in men by 57%, and type 2 diabetes is linked to female pattern hair loss. Reducing sugar intake and using treatments like finasteride and minoxidil may help manage hair loss.
community What's the best type of rosemary essential oil for stimulating hair growth? Cineole, camphor, or verbenone?
Rosemary essential oil, particularly cineole, is considered by some to be beneficial for hair growth, though its effectiveness compared to minoxidil is debated. Finasteride, minoxidil, and ketoconazole shampoo are recommended treatments, while oils like rosemary and peppermint are seen as supplementary for scalp health.
community Dutasteride might be better for your hairline. Some people have more type 1 5AR activity in their scalp than others.
Dutasteride might be better for hairline due to varying levels of 5AR activity in scalps. Genetic tests can determine if finasteride is enough or if dutasteride is needed.
community UPDATE: now 5 months on Dut and continuing to regress aggressively
The user is experiencing significant hair loss after switching from finasteride to dutasteride for five months. Suggestions include that the hair loss might be a normal shedding phase, with some recommending continuing the treatment for up to 24 months or considering alternatives like RU58841.
community M30, month 5 of dutasteride and minoxidil
A 30-year-old male experienced significant hair regrowth after five months of using topical minoxidil (5% foam) and oral dutasteride (0.5 mg daily). The user reported no side effects and was grateful for the progress, despite the rapid gains slowing down.
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4 / 801 resultslearn Stem Cell Factor
learn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
learn Overview
learn Finasteride
Frontline, gold standard treatment for combatting androgenic alopecia
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Hair TransplantHair Loss TreatmentsAlpha Beauty: Haartransplantation in HannoverHannover, Niedersachsen · DE - 33
Hair TransplantHair Loss TreatmentsSMPAlpha HaarkliniekAmsterdam · NL - 77
Hair TransplantAlpha Hair RestorationWinter Park, FL · US - 33
Hair TransplantHair Loss TreatmentsAlpha Keratix hair transplant & facial surgery clinicNagpur, Maharashtra · IN
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