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    Glossary 5α-reductase enzyme

    converts testosterone into the more potent dihydrotestosterone (DHT)

    The 5α-reductase enzyme is responsible for converting testosterone into dihydrotestosterone (DHT), a more potent androgen hormone. This enzyme plays a significant role in the development of male characteristics and is also implicated in conditions like androgenic alopecia (male pattern baldness) and benign prostatic hyperplasia (BPH).

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    Research 10 of 1000+

    1. The neurosteroidogenic enzyme 5α-reductase modulates the role of D1 dopamine receptors in rat sensorimotor gating Psychoneuroendocrinology · 2015 · 49 citations
    2. The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation Neuropsychopharmacology · 2017 · 27 citations
    3. Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites Frontiers in Neuroendocrinology · 2020 · 18 citations
    4. Effect of the 5α-reductase enzyme inhibitor dutasteride in the brain of intact and parkinsonian mice 2017 · 16 citations
    5. Enzyme Inhibitory Activities of Marine Sponges Against Cholinesterase and 5α-Reductase 2019
    6. Genetic analysis of 5 α reductase type 2 enzyme in relation to oxidative stress in cases of androgenetic alopecia in a sample of egyptian population Our Dermatology Online · 2013 · 1 citations
    7. Enzyme-linked immunosorbent assays for doping control of 5α-reductase inhibitors finasteride and dutasteride Analytica Chimica Acta · 2010 · 10 citations
    8. Glioblastoma cells express crucial enzymes involved in androgen synthesis: 3β‐hydroxysteroid dehydrogenase, 17‐20α‐hydroxylase, 17β‐hydroxysteroid dehydrogenase and 5α‐reductase Endocrinology, diabetes & metabolism · 2021 · 5 citations
    9. Theoretical Evaluation of Twenty-Cannabinoid Derivatives on Either Androgen Receptor or 5α-Reductase Enzyme Clinical cancer investigation journal · 2023 · 3 citations
    10. Design of Liposome Formulations for CRISPR/Cas9 Enzyme Immobilization: Evaluation of 5-Alpha-Reductase Enzyme Knockout for Androgenic Disorders ACS Omega · 2023
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    Community 10 of 20

    1. FCE 28260: A Forgotten 5α-Reductase Inhibitor Community · 22 Aug 2024
    2. New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase Reddit · 22 May 2024
    3. Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction Reddit · 15 Jul 2026
    4. Does caffeine inhibit 5-α-reductase? Reddit · 27 Dec 2019
    5. When you think about it blocking dht is not that big of a deal as it’s made out to be Reddit · 23 Feb 2026
    6. Sugar and Hair loss connections Reddit · 20 May 2025
    7. Dutasteride Literally Saves Your Hair Reddit · 16 Jun 2024
    8. How does dutasteride regrowth work? Reddit · 16 May 2024
    9. What About Phytosterol Alternatives - Rice Bran Oil - Natural DHT Blockers Reddit · 4 May 2024
    10. Do some people respond better to finasteride than dutasteride? Or the other way around? Reddit · 27 Jun 2023
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    Learn 1

    1. Dutasteride 5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride