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research Investigation of drug partition property in artificial sebum

33 citations , June 2007 in “International Journal of Pharmaceutics”

This study found that the sebum partition coefficient (K(sebum)) for some drugs differs from the stratum corneum partition coefficient (K(sc)), indicating its importance for targeted drug delivery into hair and sebaceous follicles.

research Testosterone 5.ALPHA.-Reductase Inhibitory Active Constituents of Piper nigrum Leaf

44 citations , January 2007 in “Biological & pharmaceutical bulletin”

This study found that Piper nigrum leaf extract showed in vivo anti-androgenic activity and potent 5α-reductase inhibitory effects, with piperine and (−)-cubebin identified as active components.

research Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics

December 2022 in “Scientific Reports”

This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.

Considering the Risk of Coloring Shampoo for Gray Hair Cover in Cosmetology and Skin Barrier: A Systematic Review

research Considering the risk of a coloring shampoo with the function of gray hair cover cosmetology and skin barrier: A systematic review

May 2023 in “Health science reports”

This review discusses the harmful effects of coloring shampoos containing trihydroxybenzene on the scalp-skin barrier and emphasizes the need for safer ingredient selection to prevent side effects.

research Formulation and Evaluation of Cimetidine as a Topical Preparation

1 citations , June 2007 in “Almustansiriya journal of pharmaceutical sciences/Al-Mustansiriyah journal of pharmaceutical sciences”

This study found that a cimetidine 10% cream with sodium lauryl sulphate significantly increased drug diffusion through mouse skin and showed promise in treating warts in a preliminary clinical trial.

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learn Thymosin Beta 4

What is Thymosin Beta 4, and why is it being researched in relation to hair follicle function and regeneration? Thymosin Beta 4 is a peptide being researched for its potential to enhance hair follicle regeneration.
How is Thymosin Beta 4 typically incorporated into experimental or advanced hair growth products? Thymosin Beta 4 is not an ingredient in any approved or regulated hair-loss product — it is an unapproved research peptide (sold online as TB-500). Published hair studies are in rats and mice only, from one research group; there are no human trials, and the same literature reports it can promote tumour growth.
What role does Thymosin Beta 4 play in scalp biology compared to traditional hair loss treatments? Thymosin Beta 4 may enhance scalp biology but lacks extensive clinical validation compared to traditional treatments.
All 5 questions on Thymosin Beta 4 →

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community 4 month hair growth update on 1mg Fin and 5mg liquid minoxidil along with HRT

203 upvotes 17 hours ago

The user shared a 4-month hair growth update using 1mg finasteride, 5mg liquid minoxidil, and hormone replacement therapy (HRT), reporting significant hair regrowth. They also use a derma stamp, scalp massages, and a DHT-blocking shampoo.

community 4 months on 0.625 mg oral minoxidil & 1 year on 0.5 mg oral finasteride

6 upvotes 1 day ago

The user has been using 0.625 mg oral minoxidil for 4 months and 0.5 mg oral finasteride for a year to address hair thinning, with noticeable regrowth, especially after adding minoxidil. They experienced initial shedding and side effects like libido loss and facial/body hair thinning, and are considering adjusting their finasteride dosage due to side effects.

community 4 months on topical dutasteride and minoxidil

6 upvotes 1 day ago

The conversation is about a 29-year-old's 4-month progress using topical dutasteride and minoxidil for hair loss. Users inquire about the specific products, dosage, and any side effects.

community 4 months 0.5mg fin/ 1ml 5% minox 30 y/o

9 upvotes 1 day ago

A 30-year-old started using 0.5mg finasteride and 5% minoxidil once daily for hair loss, experiencing positive results with minimal side effects after 4 months. The user warns about minoxidil's toxicity to cats.

community 4 months on finasteride only before and after

33 upvotes 3 days ago

The conversation is about using oral finasteride for hair loss treatment. Users discuss dosage, hairline improvement, and side effects like shedding.

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