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This study found that the sebum partition coefficient (K(sebum)) for some drugs differs from the stratum corneum partition coefficient (K(sc)), indicating its importance for targeted drug delivery into hair and sebaceous follicles.

This study found that Piper nigrum leaf extract showed in vivo anti-androgenic activity and potent 5α-reductase inhibitory effects, with piperine and (−)-cubebin identified as active components.

This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.

This review discusses the harmful effects of coloring shampoos containing trihydroxybenzene on the scalp-skin barrier and emphasizes the need for safer ingredient selection to prevent side effects.

This study found that a cimetidine 10% cream with sodium lauryl sulphate significantly increased drug diffusion through mouse skin and showed promise in treating warts in a preliminary clinical trial.

The antiandrogen 11α-hydroxyprogesterone effectively reduces skin oil and cholesterol when applied to the skin.

This study suggests that red ginseng rhizome extracts, particularly ginsenoside Ro, may promote hair re-growth in an androgenetic alopecia model due to their inhibitory activity on testosterone 5α-reductase.

This study demonstrated that minoxidil-encapsulated PLLGA nanoparticles significantly increased minoxidil delivery to hair follicles compared to a minoxidil aqueous solution in mice.

In this study, researchers developed and tested an herbal hair serum containing natural ingredients like banana flower extract and orange oil, which was stable and pH-balanced, with preliminary user feedback suggesting improved hair texture, reduced hair fall, and increased hair density.

This article discusses the various roles of steroids in vertebrate organ systems and notes several glucocorticoids that were among the Top 200 Drugs by sales in the 2010s, but it reports no new clinical findings.

This study reported that 5% minoxidil nanoparticles enhanced hair growth more effectively in mice than a commercial minoxidil solution, with significantly higher drug accumulation in the upper hair follicles.

This study found that the ALAVAX complex, containing 5-ALA and GHK peptide, may increase hair count in male pattern hair loss patients over 6 months without adverse events.

This study suggests that artificial sebum L may serve as an effective substitute for human sebum in drug transport studies, due to its similar physicochemical properties.

This case report suggests that patchy hair loss in a child may be an atypical sign of persistent head lice infestation.

This study found that the aqueous ethanol extract of Myricae Cortex demonstrated in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic effects in mouse and hamster models.

This review discusses the potential role of Garudan kizhangu ennai, a polyherbal Siddha formulation, in managing alopecia areata and highlights its various pharmacological properties, although further clinical studies are needed to confirm its efficacy.

This study developed a new HPLC method for detecting prohibited substances like minoxidil and hydrocortisone in cosmetic products, achieving high sensitivity and successful application to real-world samples.

This review highlights the need for methodologies to understand and quantify drug penetration into hair follicles as significant drug pathways, noting this area lacks comprehensive articles and reports no new results.

This study identified a new compound from fermented Carica papaya L. with moderate antioxidant and potent hair growth-stimulating activities in vitro.

This study found that topical Rosmarinus officinalis leaf extract improved hair regrowth in mice and inhibited androgen-associated mechanisms involved in hair loss.

This study found that minoxidil nanoparticles increased drug delivery to hair follicles and improved hair growth more effectively in mice than conventional minoxidil formulations.

This study found that several local vegetables from Northern Thailand demonstrated significant antioxidant and 5α-reductase inhibitory activities, suggesting their potential for development into health-promoting products.

This study found that Phyllanthus urinaria extract displayed significant anti-alopecia properties in a mouse model, showing potential as an anti-5α-reductase agent for androgenic hair loss.

This review examines studies from 2019-2022 on dietary treatments for skin diseases, highlighting various foods and supplements that may aid in managing conditions like acne, psoriasis, and alopecia areata.

Made 8 minoxidil samples; 1 cocrystal, 7 salts formed.

This case report describes a patient with an allergic sensitization to minoxidil, indicating that such patients should pursue alternative therapies to treat androgenetic alopecia.

In this study, non-obese females with early-onset androgenetic alopecia showed higher total cholesterol, LDL cholesterol, triglycerides, and atherogenic index, and lower HDL cholesterol compared to controls, suggesting an association with adverse cardiovascular risk factors.

This study found that using a formulated herbal hair oil, which includes ingredients like Nigella sativa and Cocos nucifera, reduced hair fall progressively over periods ranging from 15 to 90 days among 25 volunteers, showing greater efficacy than simple purified coconut oil.

This study found that ZnO nanoparticles in topical skin products do not penetrate beyond the outer skin layers in humans, suggesting minimal safety concerns for subdermal absorption.

This study found that Puerariae Flos extract inhibited testosterone 5α-reductase and promoted hair growth in mouse models, suggesting its potential use for treating androgenic alopecia.