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    Glossary 3D Skin Models

    laboratory-engineered tissues that mimic human skin structure

    3D Skin Models, also known as Three-Dimensional Skin Constructs or 3D Skin Equivalents, are laboratory-engineered tissues that mimic the structure and function of human skin. These models are created using layers of different cell types, such as keratinocytes and fibroblasts, to replicate the epidermis and dermis. They are used in research and testing to study skin biology, disease, and the effects of cosmetics or pharmaceuticals, providing a more accurate alternative to traditional 2D cell cultures and reducing the need for animal testing.

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    1. Research Progress on Construction Technology of 3D Human Skin Models and Its Application Prospects in Dermatology International Journal of Molecular Sciences · 2026
    2. 1344 Novel human 3D skin model for skin aging research Journal of Investigative Dermatology · 2023
    3. 3D Bioprinting Skin Equivalents: A Methodological Perspective on Human Keratinocyte and Fibroblast Models for Wound Repair and Regeneration Wound Repair and Regeneration · 2025 · 3 citations
    4. Post-Treatment of Micro-Needling with a Dexpanthenol-Containing Ointment Accelerates Epidermal Wound Healing in Human 3D Skin Models Clinical Cosmetic and Investigational Dermatology · 2023 · 2 citations
    5. Incorporation of hair follicles in 3D bioprinted models of human skin Science Advances · 2023 · 46 citations
    6. Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models Archives of Toxicology · 2018 · 38 citations
    7. The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression Journal of Visualized Experiments · 2011 · 110 citations
    8. Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging Ageing Research Reviews · 2026
    9. 3D-SeboSkin Model for Human ex vivo Studies of Hidradenitis Suppurativa/Acne Inversa Dermatology · 2021 · 4 citations
    10. In Vitro Skin Models for Pigmentary Disorders: From Reconstructed Tissues to Skin-on-a-Chip Platforms Regenerative Biomaterials · 2026
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