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Glycogen Synthase Kinase 3 Beta

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research HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and Beyond

30 citations, July 2019 in “Endocrinology”

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

research Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

20 citations, June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery”

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

research HSD3B1 Gene Polymorphism and Female Pattern Hair Loss in Women with Polycystic Ovary Syndrome

7 citations, May 2019 in “Journal of the Formosan Medical Association”

HSD3B1 gene variant and being overweight linked to hair loss in women with polycystic ovary syndrome.

Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia

research Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia

23 citations, October 2006 in “Journal of Investigative Dermatology”

Men with baldness have higher levels of specific proteins, suggesting local hormone production may play a role in hair loss.

research Effect of Eurycoma Longifolia Extract on Testosterone Synthesis in TM3 Leydig Cells Under Oxidative Stress

1 citations, July 2022 in “Han'gug sigpum yeong'yang gwahag hoeji/Journal of the Korean society of food science and nutrition”

Eurycoma longifolia extract may help increase testosterone levels and reduce andropause symptoms.

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community Possible explanation of why Dutasteride seems to be worse for some people’s hair.

in Treatment 47 upvotes 1 year ago

The conclusion of the conversation is that some individuals may experience a condition called reactionary hypergonadism when taking dutasteride for hair loss. This condition can lead to an increase in testosterone levels, which may worsen hair loss instead of improving it.

community Bile Acid-Mediated DHT Dysregulation Hypothesis

in Research/Science 13 upvotes 2 weeks ago

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 158 upvotes 11 months ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community 137 years old and still far more hair than the average r/tressless user

in Satire 1069 upvotes 1 year ago

The post and conversation are about a user claiming to be 137 years old with a full head of hair. Specific treatments mentioned include dutasteride, RU58841, and minoxidil.

community Finasteride gyno experience and in dire need of advice

in Finasteride/Dutasteride 7 upvotes 4 years ago

A user experienced puffy nipples and lumps from finasteride, leading to a dilemma between continuing treatment with potential surgery or accepting hair loss. They restarted finasteride at a lower dose with supplements but still face side effects and are seeking advice on whether to persist or stop.

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