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Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites

research Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites

18 citations, March 2020 in “Frontiers in Neuroendocrinology”

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

research New Steps Forward in the Neuroactive Steroid Field

31 citations, March 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

research Post-Finasteride Syndrome: An Emerging Clinical Problem

26 citations, December 2019 in “Neurobiology of Stress”

Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.

research Role of Anticonvulsant and Antiepileptogenic Neurosteroids in the Pathophysiology and Treatment of Epilepsy

65 citations, January 2011 in “Frontiers in Endocrinology”

Neurosteroids show promise for treating epilepsy and more research is needed.

research Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients

58 citations, April 2017 in “The Journal of Steroid Biochemistry and Molecular Biology”

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

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Community Join

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community 4 months progress on topicals and vitamins !

in Is this regrowth? 8 upvotes 7 months ago

A 24-year-old male has been using 0.1% finasteride and 5% minoxidil daily for four months, added dermarolling and topical dutasteride, and sees hair regrowth, improving from a Norwood scale 4a to 3a. He wants to optimize his hair loss treatment routine.

community Spironolactone topically with a try ?!

in Research/Science 1 upvotes 9 months ago

A 30-year-old male is considering using dutasteride and fluridil for hair loss maintenance and is curious about the effectiveness of topical spironolactone, as he cannot take finasteride. He is also planning a hair transplant.

community Hair Loss Breakthrough: Keratin Microsphere Gel Initiates Hair Regrowth in Days by Directly Targeting Follicles and Boosting Gene Expression - Gilmore Health News

in Treatment 466 upvotes 8 months ago

A new hair loss treatment involving Keratin Microsphere Gel is discussed, with skepticism and jokes about its effectiveness and comparisons to other treatments. Users are doubtful and make light of the situation, referencing past disappointments and the study's focus on mice.

community I know that wanting a cure is unrealistic and too much to ask. But I at least want medicine that will work reliably for almost everyone.

in Chat 51 upvotes 2 months ago

The conversation is about the effectiveness of hair loss treatments like finasteride, dutasteride, and minoxidil. Users agree these treatments help maintain hair but don't guarantee miraculous regrowth, emphasizing early intervention for best results.

community Clinical Trial: Clascoterone (Cortexolone 17A-Propionate)

in Research/Science 24 upvotes 7 months ago

A user is joining a clinical trial for Clascoterone, a drug approved for acne but being tested for hair loss. They previously tried finasteride with limited success and plan to share updates on their experience with the new treatment.

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