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Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid

research Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-caffeoylquinic acid (TCQA)

November 2021 in “Research Square (Research Square)”

This study found that human hair follicle dermal papilla cells grown in a 3D model influenced hair growth and immune pathways more effectively than those grown in a 2D culture.

research 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging

3 citations , April 2025 in “International Journal of Molecular Sciences”

This review evaluates the anti-aging properties of TSG from He shou wu, finding it may protect against age-related diseases through multiple mechanisms, though further research is needed for clinical application.

research Development of 3-D Microbioreactor Systems for Cell-Based High Throughput Screening

1 citations , June 2012 in “OhioLink ETD Center (Ohio Library and Information Network)”

In this study, the 40-MBR system was shown to enhance drug-screening efficiency by providing reliable, real-time monitoring of cell conditions in 3-D cultures compared to traditional methods.

research Allergic Contact Dermatitis of the Scalp Associated With Scalp Applied Products: A Systematic Review of Topical Allergens.

5 citations , July 2022 in “PubMed”

This study identified the most common allergens in hair products linked to scalp allergic contact dermatitis, with hair dyes, shampoos, and conditioners primarily associated with the condition.

research Lymphatic remodeling and metabolic rescue by VEGFR-3/DHA-coordinated microneedles for hair regeneration

February 2026 in “Nano Research”

This study developed a dissolvable microneedle system delivering specific molecules to remodel lymphatic networks and normalize metabolic processes, which accelerated hair growth and activated hair follicle stem cells in a mouse model of androgenetic alopecia.

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Community Join

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community Norwood 3.5 to Norwoord 5 wuth diffused thinning: damaged follicles all over the scalp due to 2 years of hair system usage. Has anyone faced a similar nightmare and recovered or revived their follicles? Desperately need help guys!

6 upvotes 3 years ago

User experienced hair loss from Norwood 3.5 to Norwood 5 with diffuse thinning after using a hair system for 2 years. Tried Redensyl, Capixyl, Bicapil, Biotin, multivitamins, Fin, and Min without significant improvement, seeking advice for hair recovery.

community 3 surgery total 7600 Grafts surgery journey

726 upvotes 7 months ago

A person had three hair transplant surgeries using 7,600 grafts from scalp, beard, and chest, along with finasteride and minoxidil. Reactions are mixed, with suggestions for alternatives like hair systems or scalp micropigmentation.

community Breezula Phase 3 Results enough for maintenance?

13 upvotes 4 months ago

Breezula shows promise in stabilizing hair loss and potentially promoting regrowth at the one-year mark, offering hope for those who can't tolerate 5AR inhibitors. Its local targeting of androgen receptors could be a significant advancement if it avoids systemic side effects.

community Going on the big 3 for the first time. What blood tests do I need to do (initially and ongoing)?

4 upvotes 1 month ago

A man in his 40s is considering starting finasteride, oral minoxidil, and Nizoral shampoo for hair loss, with concerns about side effects like gynecomastia and brain fog. He is advised to consider blood tests for monitoring, with some users suggesting topical treatments to reduce systemic side effects.

community 23M 10.5 months into 3-6mg Minoxodil 1mg Finasteride. Realistic, Limited Progress despite HIGH DOSE.

9 upvotes 4 months ago

A 23-year-old male is experiencing aggressive hair loss despite using 1mg finasteride and 4.5mg minoxidil, with limited progress and side effects like fluid retention. Suggestions include trying dutasteride, microneedling with topical minoxidil, and considering hair systems or a transplant in the future.

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Learn

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learn Scalp Micropigmentation

Does scalp micropigmentation look natural? Scalp micropigmentation can look natural if performed by a skilled practitioner.

learn Hair Transplant

Who is a good candidate for a hair transplant? Good candidates for hair transplants have sufficient donor hair and stable hair loss patterns.

learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Thymosin Beta 4

learn Omega 3

Did you know omega-3 can lower scalp inflammation that leads to sudden hair loss? Omega-3 can reduce scalp inflammation, potentially preventing sudden hair loss.
Is the omega-3 to omega-6 ratio in your diet feeding your hair problem without you knowing? Nutrition sources describe a lopsided omega-6 to omega-3 intake as pro-inflammatory, but no published human study shows that the dietary ratio changes 5-alpha reductase, scalp DHT or hair loss; the one relevant trial tested a commercial omega-3/6 plus antioxidant supplement in 120 women, not a change in dietary fat ratio.
How can omega-3 supplements help reduce hair loss and support healthy hair growth? Omega-3 supplements may reduce hair loss by improving scalp health and circulation.

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