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Glossary3β-Hydroxysteroid Dehydrogenase

enzyme crucial for converting steroid precursors into active hormones

3β-Hydroxysteroid Dehydrogenase (3β-HSD) is an enzyme that plays a crucial role in the biosynthesis of all classes of hormonal steroids, including androgens, estrogens, and glucocorticoids. It catalyzes the conversion of Δ5-3β-hydroxysteroids to Δ4-3-ketosteroids, a key step in the production of hormones that regulate various physiological processes, including hair growth and skin health.

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Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

research Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

5 citations , July 2021 in “Endocrinology, diabetes & metabolism”

Glioblastoma cells can make androgens, which might help the tumor grow.

Urinary 5-Ene-Steroid Excretion in Non-Classical Congenital Adrenal Hyperplasia Due to 3β-Hydroxysteroid Dehydrogenase Deficiency

research Urinary 5-Ene-Steroid Excretion in Non-Classical Congenital Adrenal Hyperplasia Due to 3β-Hydroxysteroid Dehydrogenase Deficiency

3 citations , May 1990 in “Journal of Steroid Biochemistry”

Some women with excess hair growth have a hormone condition that can't be diagnosed by blood or urine tests alone.

research A Platform for Determining Medicinal Plants with Targeted 17β-Hydroxysteroid Dehydrogenase Modulation for Possible Hair Loss Prevention

February 2024 in “Cosmetics”

The conclusion is that new plant-based treatments for hair loss may work by targeting certain enzymes.

research Delayed Diagnosis of Congenital Adrenal Hyperplasia Due to 3β-Hydroxysteroid Dehydrogenase Type 2 Deficiency

September 2025 in “JCEM Case Reports”

Consider rare forms of CAH for accurate diagnosis and treatment.

research An Adult With Hair Loss: A Rare Case of Non-Classical 3β Hydroxysteroid Dehydrogenase Deficiency

May 2021 in “Journal of the Endocrine Society”

A woman's hair loss and other symptoms were due to a rare hormone deficiency treatable with steroids.

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community How I started reversing Male Pattern Baldness naturally ?

in Question 7 upvotes 8 years ago

The user reversed male pattern baldness using a pro-thyroid diet, lifestyle changes, and scalp stimulation exercises, without Minoxidil or Finasteride. They reported reduced dandruff, itchiness, oiliness, and experienced hair regrowth and thickening over 15 months.

community Bile Acid-Mediated DHT Dysregulation Hypothesis

in Research/Science 13 upvotes 11 months ago

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

community "but it will hurt my gains bro"

in Satire 1309 upvotes 1 year ago

The conversation humorously discusses hair loss treatments like Minoxidil, Finasteride, and Dutasteride, and their effects on hair and muscle gains. Users debate effectiveness and side effects, mixing scientific approaches with jokes.

community The theory that explains everything. Please help me make this big!

in Research/Science 2453 upvotes 4 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

community GT20029 and PP405 the new fin and min that we been waiting for ?

in Chat 35 upvotes 4 months ago

PP405 and GT20029 are new hair loss treatments with different mechanisms from traditional options like Minoxidil and Finasteride. PP405 targets hair follicle stem cells to reactivate growth, while GT20029 works as an androgen receptor deleter, both requiring ongoing use for effectiveness.

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