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    Glossary 3β-Hydroxysteroid Dehydrogenase

    enzyme crucial for converting steroid precursors into active hormones

    3β-Hydroxysteroid Dehydrogenase (3β-HSD) is an enzyme that plays a crucial role in the biosynthesis of all classes of hormonal steroids, including androgens, estrogens, and glucocorticoids. It catalyzes the conversion of Δ5-3β-hydroxysteroids to Δ4-3-ketosteroids, a key step in the production of hormones that regulate various physiological processes, including hair growth and skin health.

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    Research 10 of 693

    1. Structure and Expression of a New Complementary DNA Encoding the almost Exclusive 3β-Hydroxysteroid Dehydrogenase/Δ<sup>5</sup>-Δ<sup>4</sup>-lsomerase in Human Adrenals and Gonads Molecular Endocrinology · 1991 · 354 citations
    2. Glioblastoma cells express crucial enzymes involved in androgen synthesis: 3β‐hydroxysteroid dehydrogenase, 17‐20α‐hydroxylase, 17β‐hydroxysteroid dehydrogenase and 5α‐reductase Endocrinology, diabetes & metabolism · 2021 · 5 citations
    3. Urinary 5-ene-steroid excretion in non-classical congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency (NC-3BHSD) Journal of Steroid Biochemistry · 1990 · 3 citations
    4. Delayed Diagnosis of Congenital Adrenal Hyperplasia Due to 3β-Hydroxysteroid Dehydrogenase Type 2 Deficiency JCEM Case Reports · 2025
    5. An Adult With Hair Loss! a Rare Case of Non-Classical 3β Hydroxysteroid Dehydrogenase (3β HSD) Deficiency Journal of the Endocrine Society · 2021
    6. Effect of  3-Beta Hydroxysteroid Dehydrogenase on Serum Testosterone Level in Obese Women With Polycystic Ovary Syndrome Journal of Kufa for Chemical Sciences · 2025
    7. Δ5-3β-Hydroxysteroid Dehydrogenase Activity in Sebaceous Glands of Scalp in Male-Pattern Baldness Journal of Investigative Dermatology · 1988 · 69 citations
    8. Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2006 · 23 citations
    9. A Platform for Determining Medicinal Plants with Targeted 17β-Hydroxysteroid Dehydrogenase Modulation for Possible Hair Loss Prevention Cosmetics · 2024
    10. Results of clinical examinations, laboratory tests, and ultrasonography in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane American journal of veterinary research · 2002 · 116 citations
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