Search
for

    Glossary 3β-Hydroxysteroid Dehydrogenase

    enzyme crucial for converting steroid precursors into active hormones

    3β-Hydroxysteroid Dehydrogenase (3β-HSD) is an enzyme that plays a crucial role in the biosynthesis of all classes of hormonal steroids, including androgens, estrogens, and glucocorticoids. It catalyzes the conversion of Δ5-3β-hydroxysteroids to Δ4-3-ketosteroids, a key step in the production of hormones that regulate various physiological processes, including hair growth and skin health.

    Related Terms

    Sort by

    Research 30 of 694

    1. Structure and Expression of a New Complementary DNA Encoding the almost Exclusive 3β-Hydroxysteroid Dehydrogenase/Δ<sup>5</sup>-Δ<sup>4</sup>-lsomerase in Human Adrenals and Gonads Molecular Endocrinology · 1991 · 354 citations
    2. Glioblastoma cells express crucial enzymes involved in androgen synthesis: 3β‐hydroxysteroid dehydrogenase, 17‐20α‐hydroxylase, 17β‐hydroxysteroid dehydrogenase and 5α‐reductase Endocrinology, diabetes & metabolism · 2021 · 5 citations
    3. Urinary 5-ene-steroid excretion in non-classical congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency (NC-3BHSD) Journal of Steroid Biochemistry · 1990 · 3 citations
    4. Delayed Diagnosis of Congenital Adrenal Hyperplasia Due to 3β-Hydroxysteroid Dehydrogenase Type 2 Deficiency JCEM Case Reports · 2025
    5. An Adult With Hair Loss! a Rare Case of Non-Classical 3β Hydroxysteroid Dehydrogenase (3β HSD) Deficiency Journal of the Endocrine Society · 2021
    6. Effect of  3-Beta Hydroxysteroid Dehydrogenase on Serum Testosterone Level in Obese Women With Polycystic Ovary Syndrome Journal of Kufa for Chemical Sciences · 2025
    7. Δ5-3β-Hydroxysteroid Dehydrogenase Activity in Sebaceous Glands of Scalp in Male-Pattern Baldness Journal of Investigative Dermatology · 1988 · 69 citations
    8. Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2006 · 23 citations
    9. A Platform for Determining Medicinal Plants with Targeted 17β-Hydroxysteroid Dehydrogenase Modulation for Possible Hair Loss Prevention Cosmetics · 2024
    10. Results of clinical examinations, laboratory tests, and ultrasonography in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane American journal of veterinary research · 2002 · 116 citations
    11. Treatment of canine Alopecia X with trilostane Veterinary Dermatology · 2004 · 40 citations
    12. Baicalin inhibits recruitment of GATA1 to the HSD3B2 promoter and reverses hyperandrogenism of PCOS Journal of Endocrinology · 2019 · 12 citations
    13. Hirsutism-A Comprehensive Update of Embryology, Aetiopathogenesis and Therapeutic Approach Journal of gynecology and womens health · 2017 · 1 citations
    14. The Use of Trilostane for the Treatment of Alopecia X in Alaskan Malamutes 2005 · 15 citations
    15. Pre-receptor regulation of the androgen receptor Molecular and cellular endocrinology · 2007 · 56 citations
    16. MALE PSEUDOHERMAPHRODITISM DUE TO 17β-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY: STUDIES ON THE NATURAL HISTORY OF THE DEFECT AND EFFECT OF ANDROGENS ON GENDER ROLE Elsevier eBooks · 1983
    17. Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System Androgens · 2021 · 1 citations
    18. Current evidence for the involvement of sex steroid receptors and sex hormones in benign prostatic hyperplasia Research and Reports in Urology · 2019 · 26 citations
    19. 25 years of ERβ: a personal journey Journal of molecular endocrinology · 2021 · 11 citations
    20. Hétérogénéité tumorale du cancer de la prostate et infection par le SARS-CoV2 : une relation complexe impliquant les vésicules extracellulaires et le récepteur des androgènes SPIRE - Sciences Po Institutional REpository · 2023
    21. Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands 2019 · 16 citations
    22. A high-performance liquid chromatography–tandem mass spectrometry assay of the androgenic neurosteroid 3α-androstanediol (5α-androstane-3α,17β-diol) in plasma Steroids · 2005 · 19 citations
    23. Mechanism of action of bolandiol (19-nortestosterone-3β,17β-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities 2009 · 11 citations
    24. Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol Neuroscience · 2004 · 136 citations
    25. Activity of 17β-(N-Alkyl/arylformamido) and 17β-[(N-Alkyl/aryl) alkyl/arylamido]-4-methyl-4-aza-5α-androstan-3-ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear11The research has been supported by Endorecherche that is seeking patent protection for the new compounds. F. Labrie is President of Endorecherche. Journal of Investigative Dermatology · 1998 · 10 citations
    26. Effect of <i>Eurycoma longifolia</i> Extract on Testosterone Synthesis in TM3 Leydig Cells under Oxidative Stress 2022 · 1 citations
    27. New Nonsteroidal Molecules as Blockers of the Steroidogenic Pathway Current Enzyme Inhibition · 2022
    28. Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla Journal of Investigative Dermatology · 2001 · 61 citations
    29. Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin 2010 · 46 citations
    30. Inhibiting Biosynthesis and/or Metabolism of Progestins in the Ventral Tegmental Area Attenuates Lordosis of Rats in Behavioural Oestrus Journal of Neuroendocrinology · 2005 · 36 citations