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      learn Alfatradiol

      a synthetic estrogen used topically as an anti-androgen

      learn Cyproterone

      a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

      learn Clascoterone

      a novel topical treatment that inhibits DHT on androgen receptors

      learn Estradiol

      an estrogen promoting hair regrowth more commonly used in women

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      community Mechanism of action of alfatradiol (17 alpha estradiol)

      in Research/Science  6 upvotes 4 months ago
      The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

      community Any long term diffuse thinners success stories?

      in Chat  27 upvotes 1 year ago
      A user with early-stage diffuse hair thinning asked for long-term success stories using treatments like finasteride, minoxidil, and RU58841. One person regained most of their hair after 22 months on finasteride and minoxidil, while another saw significant improvement with oral minoxidil after trying various treatments over many years.

      community 22 years since the last major development

      in Technology  51 upvotes 3 years ago
      The conversation discusses the lack of significant advancements in hair loss treatments since the introduction of finasteride 22 years ago, with many expressing frustration over the failure of new projects and skepticism about future developments. Some users mention hair transplants and other potential alternatives like Alfatradiol and Fluridil, but acknowledge finasteride's dominance in the market due to its effectiveness and affordability.

      community Why do barbers never mention if you’re balding?

      in Chat  317 upvotes 6 months ago
      People are discussing why barbers often don't mention their clients' hair loss, with some sharing personal experiences where barbers did suggest treatments like finasteride (Fin) or mentioned the possibility of hair transplants. Some barbers avoid the topic to not offend clients, while others openly discuss it and recommend treatments or acknowledge the issue when asked.