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Glossary15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2)

lipid compound with anti-inflammatory and immune-regulating properties

15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is a type of prostaglandin, which are lipid compounds that have hormone-like effects in the body. 15d-PGJ2 is known for its anti-inflammatory properties and its role in regulating immune responses. It can also influence cell growth and differentiation, making it relevant in studies related to hair growth and alopecia.

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research Topical Administration of 15-Deoxy-Δ12,14-Prostaglandin J2 Using a Nonionic Cream: Effect on UVB-Induced Skin Oxidative, Inflammatory, and Histopathological Modifications in Mice

9 citations , January 2021 in “Mediators of Inflammation”

15d‐PGJ2 cream protects against UVB-induced skin damage in mice.

Divergent Proliferation Patterns of Distinct Human Hair Follicle Epithelial Progenitor Niches In Situ and Their Differential Responsiveness to Prostaglandin D2

research Divergent Proliferation Patterns of Distinct Human Hair Follicle Epithelial Progenitor Niches In Situ and Their Differential Responsiveness to Prostaglandin D2

21 citations , November 2017 in “Scientific Reports”

Different human hair follicle stem cells grow at different rates and respond differently to a baldness-related compound.

research A New Target for Squamous Cell Skin Cancer?

6 citations , October 2014 in “Experimental Dermatology”

Prostaglandins and the enzyme AKR1C3 could play a role in skin cancer and hair loss, and further research is needed to understand these mechanisms.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

January 2016 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

A substance called prostaglandin D2 is found more in bald scalps and it stops hair from growing. Blocking its receptor could potentially treat hair loss.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

May 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Prostaglandin D2, found in higher levels in bald scalps, stops hair growth, suggesting that blocking its receptor could potentially treat hair loss.

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community You will lose hair if your prostaglandins aren't in balance

in Research/Science 56 upvotes 8 months ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

community Progress Pics 2 years fin 1mg, 1 year min

in Progress Pictures 277 upvotes 1 year ago

A user shared their hair loss progress after 2 years of finasteride and 1 year of minoxidil, along with occasional microneedling and regular exercise. They experienced initial shedding but saw significant improvement after 4 months.