The G1/S Transition in Mammalian Stem Cells In Vivo Is Autonomously Regulated by Cell Size

    Shicong Xie, Shuyuan Zhang, Gustavo de Medeiros, Prisca Liberali, Jan M. Skotheim
    Studysummary This study observed that in adult mice, a cell-autonomous size control mechanism involving the RB pathway determines the timing of S phase entry in epidermal stem cells based on their size, while external microenvironment factors influence growth rates but not this intrinsic coupling.
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