Live Imaging Reveals Chromatin Compaction Transitions and Dynamic Transcriptional Bursting During Stem Cell Differentiation In Vivo

    March 2023 in “ eLife ”
    Dennis May, Sangwon Yun, David G. Gonzalez … Valentina Greco
    Studysummary This study reveals that epidermal stem cell differentiation in mice involves dynamic transcriptional changes, with Keratin-10 transcription preceding gradual chromatin compaction shifts associated with differentiation.
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    Research cited in this study 3

    1. Intravital Imaging of Hair Follicle Regeneration in the Mouse Nature Protocols · 2015
    2. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    3. Conditional Expression of the ErbB2 Oncogene Elicits Reversible Hyperplasia in Stratified Epithelia and Up-Regulation of TGFα Expression in Transgenic Mice Oncogene · 1999