Skin Hyperpigmentation in Complex Regional Pain Syndrome
April 2015
in “
Neurology
”
Studysummary This study found that hyperpigmented skin changes resembling Schamberg’s purpura occur in areas affected by CRPS and can also appear on mirror-image locations of unaffected limbs, potentially improving with the condition's treatment.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study aimed to characterize hyperpigmented skin changes in limbs affected by Complex Regional Pain Syndrome (CRPS). CRPS is a challenging neuropathic pain syndrome with subjective symptoms like burning pain, making early diagnosis difficult. The study found that skin pigmentation increased in areas with CRPS symptoms, such as swelling and altered hair growth, and also in mirror-image locations on opposite limbs. Unlike Schamberg’s purpura, these pigmentation changes improved with the alleviation of CRPS symptoms, suggesting a neurogenic or humoral mechanism. The study did not receive external support, and Dr. Knobler disclosed compensation from pharmaceutical companies.
