Women Also Use 5α-Reductase Inhibitors—Reply

The document discussed the use of 5α-reductase inhibitors in women, noting that these medications, typically used for conditions like hirsutism and alopecia, can increase estrogen levels. It emphasized the importance of recognizing sex-specific responses to hormonal treatments, as androgen excess in women can lead to cardiometabolic disorders, unlike androgen deficiency in men. The authors acknowledged the limitations of the original study by Welk et al., which focused on men over 65 and excluded younger men and the small number of women using these medications, and supported the need for more broadly generalizable studies.