Why Waiting for Godot Could Not Be an Ideal Technique to Generate Scientific Data

The editorial discusses the challenges in collecting scientific data for the topical treatment of wounds, highlighting the scarcity of studies and the criticism regarding the quality and artificial nature of existing research. It likens the wait for a perfect study that addresses all relevant questions and accurately reflects clinical reality to the futile wait for Godot, suggesting it is an endless and impossible endeavor. To overcome this dilemma, the editorial proposes two solutions: the creation of a clinical registry to systematically mirror clinical reality and the incremental collection of relevant data to validate clinical work. The article by Ciliberti and colleagues is presented as a step in this direction, acknowledging that while it may not meet the highest scientific standards, it contributes truthfully to the larger clinical puzzle of managing microbial bioburden. The editorial concludes by expressing a decision to publish the article to foster discussion and encourage the submission of clinical studies, even if they do not answer all questions in wound medicine.