The Role of Vitamin D for the Management of Depression in the Western Ukrainian Population with Autoimmune Thyroiditis and Hypothyroidism
November 2022
in “
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)
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Studysummary This study found that supplementing cholecalciferol with L-thyroxine significantly reduced depression levels in hypothyroid patients with autoimmune thyroiditis compared to L-thyroxine alone.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study investigated the impact of vitamin D (cholecalciferol) supplementation on depression levels in 56 patients with hypothyroidism due to autoimmune thyroiditis in Western Ukraine. Depression severity was assessed using the Hamilton Depression Rating Scale over a 12-week treatment period. Results showed that patients receiving both cholecalciferol and L-thyroxine experienced a 40% reduction in depression levels, compared to a 25% reduction in those receiving only L-thyroxine. Additionally, 21.4% of patients in the cholecalciferol group saw complete remission of depression, while no complete remission was observed in the L-thyroxine-only group. The study concluded that vitamin D supplementation could effectively manage depression in patients with autoimmune thyroiditis and hypothyroidism.