Utilization of nanotechnology and experimental design in development and optimization of Aloe vera gel loaded with Finasteride‒Garlic Oil‒Nanotransfersomes
January 2022
in “Journal of Drug Delivery Science and Technology”
TLDR A gel made with finasteride, garlic oil, and Aloe vera using nanotechnology can potentially treat hair loss more effectively.
The study aimed to improve the solubility and dermal permeation of finasteride, a drug used for treating alopecia, by developing a topical nanotransferosomal gel loaded with finasteride, garlic oil, and Aloe vera. The researchers used nanotechnology and experimental design to optimize the gel. The nanotransferosomal system was chosen due to its ability to deliver drugs to specific sites with better permeation and efficacy. Garlic oil and Aloe vera were included for their antimicrobial properties and potential to promote hair growth. The study concluded that the optimized formulation had the smallest possible globule size, maximum encapsulation efficiency, higher steady-state flux, and minimum inhibitory concentration value against Propionibacterium acnes, a bacteria causing scalp infection in alopecia. The study suggests that this formulation could be a promising approach for alopecia treatment.
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research Finasteride, 1 mg (Propecia), Is the Optimal Dose for the Treatment of Men With Male Pattern Hair Loss
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