Utility of Horizontal Sections of Scalp Biopsies in Differentiating Between Androgenetic Alopecia and Alopecia Areata

    January 2018 in “ Figshare ”
    Devendra Kumar Yadav, Sujay Khandpur, M Ramam, Manoj Kumar Singh, Vinod Sharma
    Image of study
    TLDR Horizontal sections of scalp biopsies are useful for telling the difference between Androgenetic Alopecia and Alopecia Areata.
    The study, conducted from March 2015 to September 2016, aimed to differentiate between Androgenetic Alopecia (AGA) and Alopecia Areata (AA) using horizontal sections of scalp biopsies. The research was carried out in the Departments of Dermatology and Venereology, and Pathology, All India Institute of Medical Sciences, New Delhi. The study included patients diagnosed with AGA and AA, excluding those under 18, under treatment for alopecia, or with active scalp infection. Biopsies were taken from the edge of the alopecic patch and the uninvolved occipital area of the scalp in men with AGA. The biopsies were then sectioned and stained for examination. Various histological features were assessed and recorded, including the total number of hair follicles, number of terminal and vellus hair, anagen hair, non-anagen hair, and vascular stelae. The data was analyzed using Stata 12.0 software, with statistical significance assessed using Fisher’s exact test and the Kruskal-Wallis test.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community Do hair follicles dies or are dormant ?

      in Finasteride/Dutasteride  92 upvotes 1 month ago
      Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.

      community To anyone that is still not seeing results on the big 3…

      in Treatment  105 upvotes 2 years ago
      User redh0t12 suggests using a derma pen for hair regrowth, as it helped them after using finasteride and minoxidil. Others discuss their experiences with various treatments, including derma rolling, oral and topical minoxidil, and finasteride, with mixed results.

      community HLT Megathread on HMI-115 (key takeaways in comments)

      in Research/Science  37 upvotes 1 year ago
      HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

      community How essential is scalp biopsy when dealing with hair loss?

      in Treatment  6 upvotes 2 months ago
      The user experienced hair loss despite using Fin and Min for 12 years and switched to Dutasteride, RU58841, and Keto scalp serum, but shedding and itch persist. They are considering increasing Dutasteride to 2.5mg and questioning the necessity of a scalp biopsy, with mixed opinions on its usefulness.

    Related Research

    4 / 4 results