High-Coverage Genome of the Tyrolean Iceman Reveals Unusually High Anatolian Farmer Ancestry

    August 2023 in “ Cell Genomics ”
    Ke Wang, Kay Prüfer, Ben Krause‐Kyora, Ainash Childebayeva, Verena J. Schuenemann, Valentina Coia, Frank Maixner, Albert Zink, Stephan Schiffels, Johannes Krause
    The high-coverage genome analysis of the Tyrolean Iceman reveals an unusually high proportion of Anatolian farmer ancestry, with 91.4% of his genome attributed to early Neolithic farmers and only 8.6% to Western European hunter-gatherers, contradicting previous findings of Steppe-related ancestry. The Iceman likely had darker skin, black hair, reduced hair curliness, and a genetic predisposition to male-pattern baldness, type 2 diabetes, and obesity-related metabolic syndrome. The study suggests the Iceman's genetic makeup reflects an isolated Alpine population, distinct from more admixed European populations, and highlights the need for further research to determine if he was an outlier or typical of his region.
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