TLDR Dermatologists should consider congenital syndromes like TRPS in young adults with early hair loss.
Trichorhinophalangeal syndrome (TRPS) was characterized by a combination of hair, facial, and bone abnormalities with varying expression. A case study of a 20-year-old man with TRPS highlighted marked androgenetic alopecia. Scanning electron microscopy showed the hair had a flattened, elliptoid transverse section, and its mechanical behavior was abnormal, with increased viscosity suggesting decreased intermolecular bridging in the keratin matrix. The study suggested that dermatologists should consider congenital syndromes like TRPS when encountering premature or marked alopecia in young adults, warranting further investigation.
26 citations
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July 2019 in “Dermatology and Therapy” The conclusion is that genetic testing is important for diagnosing and treating various genetic hair disorders.
11 citations
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May 2011 in “World Journal of Pediatrics” The document emphasizes the importance of correctly identifying and classifying genetic hair disorders to help diagnose related health conditions.
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April 2020 in “Journal of dermatology” A person with a specific gene mutation had extra teeth, unique jaw and hair features not seen before in this condition.
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January 2017 in “Annals of Dermatology” The study found genetic differences related to hair development that may explain hair loss in a patient with Trichorhinophalangeal syndrome type I.
89 citations
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September 2010 in “Annual Review of Genomics and Human Genetics” The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.
