Trichorrhexis Nodosa: A Distinctive Presentation After Tumor Necrosis Factor-Alpha Inhibitor Therapy

This article describes a case of localized trichorrhexis nodosa in a patient with otherwise normal hair, highlighting the condition's response to trauma and diagnostic process but reporting no new clinical findings.

In this case report, a 24-year-old male with acquired distal trichorrhexis nodosa showed significant improvement after avoiding harmful hair treatments and using a repair shampoo alongside biotin and zinc supplements.

This study describes a distinctive hair loss pattern with features of psoriasis and alopecia areata linked to TNF-α inhibitors, noting various management options despite the lack of consensus guidelines.

This case series highlights that anti-TNF agents, though beneficial for autoimmune conditions, can cause a rare adverse reaction of psoriasiform alopecia areata, stressing the importance of specific histopathological features for accurate diagnosis and better management to avoid unnecessary drug discontinuation.

This study found that trichorrhexis nodosa, a common cause of unexplained hair loss, is primarily caused by trauma rather than a metabolic defect.