Psoriatic Alopecia/Alopecia Areata-Like Reactions Secondary to Anti-Tumor Necrosis Factor-Alpha Therapy

August 2025 in “ Australasian Journal of Dermatology ”

Lucinda Liu, Ethan La, Thien Vo, Jacinta Chronowski‐Wong, Tim T Khamu, Lachlan Warren, Alain Khoi Tran

anti-tumour necrosis factor TNF psoriasiform alopecia areata psoriatic alopecia alopecia areata

Studysummary This case series highlights that anti-TNF agents, though beneficial for autoimmune conditions, can cause a rare adverse reaction of psoriasiform alopecia areata, stressing the importance of specific histopathological features for accurate diagnosis and better management to avoid unnecessary drug discontinuation.

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research TNF-Inhibitor Associated Psoriatic Alopecia: Diagnostic Utility of Sebaceous Lobule Atrophy

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This study describes tumor necrosis factor inhibitor-associated psoriatic alopecia, highlighting the distinctive histologic feature of sebaceous lobule atrophy, which is potentially reversible and helps differentiate it from idiopathic psoriatic alopecia.

research Adalimumab-Related Alopecia in a Patient Affected by Psoriasis

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This case report describes a patient with psoriasis who developed alopecia with unique histological features after anti-TNF therapy, suggesting that such effects may require considering treatment suspension for severe cases.

Psoriatic Alopecia/Alopecia Areata–Like Reactions Secondary to Anti–Tumor Necrosis Factor-α Therapy: A Novel Cause of Noncicatricial Alopecia

research Psoriatic Alopecia/Alopecia Areata–Like Reactions Secondary to Anti–Tumor Necrosis Factor-α Therapy: A Novel Cause of Noncicatricial Alopecia

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This study found that anti-TNF therapy-induced alopecia exhibits distinct clinical and histopathological features and can mimic psoriatic alopecia and alopecia areata, with some patients improving with topical treatment.