Transplanted Hair Follicle Stem Cells Migrate to the Penumbra and Express Neural Markers in a Rat Model of Cerebral Ischaemia/Reperfusion

May 2020 in “ Research Square (Research Square) ”

Xuemei Zhang, Hao Tang, Senlin Mao, Bing Li, Yinglian Zhou, Hui Yue, Duo Wang, Yifei Wang, Jin Fu

TLDR Hair follicle stem cells may help treat strokes.

The study investigated the potential of hair follicle stem cells (HFSCs) in treating ischaemic stroke using a rat model. Researchers administered HFSCs intravenously and found that these cells migrated to the penumbra, expressed neuron-specific markers, reduced infarct volume, and promoted neurological recovery. The findings suggested that HFSC transplantation could have therapeutic potential for ischaemic stroke, indicating a promising avenue for future clinical development.

View this study on researchsquare.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Uncomplicated Differentiation of Stem Cells Into Bipolar Neurons and Myelinating Glia

33 citations , September 2008 in “Biochemical and Biophysical Research Communications”

Hair follicles can be used to easily create neurons and glial cells for potential nerve repair.

research Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles

344 citations , June 2006 in “American Journal Of Pathology”

Human hair follicles can provide stem cells for regenerative medicine.

research Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves

319 citations , November 2005 in “Proceedings of the National Academy of Sciences”

Hair follicle stem cells can help repair damaged nerves.

research Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons

419 citations , March 2005 in “Proceedings of the National Academy of Sciences”

Hair-follicle stem cells can become neurons.

research Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells

212 citations , August 2004 in “Proceedings of the National Academy of Sciences”

Hair follicle cells can create new blood vessels in the skin.

Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

130 citations , January 1994 in “Differentiation”

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.