Treatment of Central Centrifugal Cicatricial Alopecia with Topical Metformin 10% Cream: Case Report and Literature Review

June 2024 in “ International Journal of Dermatology ”

Bárbara Vieira Granja, Pedro Matos, Gilberto Pires da Rosa, Jorge Pinheiro, Filomena Azevedo, Ana Filipa Pedrosa

central centrifugal cicatricial alopecia CCCA topical metformin metformin anti-fibrotic properties hair regrowth

TLDR Topical metformin 10% cream may help treat central centrifugal cicatricial alopecia.

The document reports a case study and literature review on the use of topical metformin 10% cream for treating central centrifugal cicatricial alopecia (CCCA). The authors present a case where a patient with CCCA showed significant improvement after using the topical metformin treatment. This case adds to the limited but growing body of evidence suggesting that metformin, known for its anti-fibrotic properties, may be effective in treating CCCA. The review also highlights previous studies and cases that support the potential of metformin in promoting hair regrowth in patients with this condition. No conflicts of interest or funding sources were reported.

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Research cited in this study

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research Hair Regrowth in Two Patients with Recalcitrant Central Centrifugal Cicatricial Alopecia After Use of Topical Metformin

24 citations, January 2020 in “JAAD Case Reports”

Topical metformin helped regrow hair in two women with a hard-to-treat scarring hair loss condition.

research Fibroproliferative Genes Are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia

25 citations, June 2018 in “Journal of The American Academy of Dermatology”

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