Employment of Current Results of Tissue Engineering in the Development of Skin Substitutes

    January 2012 in “ PubMed ”
    Jana Dragúńová, Ján Koller, Cucorová
    TLDR Tissue engineering advancements are improving skin substitutes for better burn treatment.
    The document discussed the advancements in tissue engineering for developing skin substitutes, particularly for treating extensive burns to reduce patient mortality. It highlighted the use of allogeneic and autologous skin substitutes, as well as biosynthetic and combined substitutes that mimic normal skin's structure and functions. Various substitutes, including cultured keratinocytes, composites, acellular matrices, and matrices seeded with different cell types, were mentioned. The research aimed to create a fully functional skin substitute capable of revascularization, reinnervation, and replacing skin appendages like hair follicles and sebaceous glands. Achieving this required collaboration across multiple scientific disciplines. The article provided information on the skin substitutes available at that time and expressed optimism about future developments.
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