Therapeutic Effect of Spironolactone in Hyperandrogenism Syndrome

    January 1993 in “ Проблемы Эндокринологии ”
    Д. Е. Шилин, И И Дедов, Е. А. Григорьева
    Image of study
    TLDR Spironolactone effectively reduces symptoms of hyperandrogenism but has some side effects.
    The document discussed the therapeutic effects of spironolactone (SL) in treating hyperandrogenism syndrome, including conditions like hirsutism, acne, seborrhea, and androgenic alopecia. SL was effective in reducing symptoms by blocking androgen receptors, inhibiting 5α-reductase activity, and influencing steroid metabolism. Clinical studies showed significant improvements in hirsutism, acne, and hair growth, with one study reporting a 47% reduction in hirsutism scores after 6 months of treatment. However, side effects such as gynecomastia in men, menstrual irregularities in women, and gastrointestinal and central nervous system disturbances were noted. The document emphasized the need for effective antiandrogenic treatments and the potential of SL, despite limited availability and research in the Soviet Union at the time.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 415 results

      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  37 upvotes 6 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community Spironolactine Update: 2 months (34, Female)

      in Female  21 upvotes 8 years ago
      A female user's experience using Spironolactone to treat Female Pattern Hair Loss (FPHL) and Androgenic Alopecia, as well as discussing the effectiveness of the drug at different dosages.

      community Spironolactone and pregnancy planning

      in Female  2 upvotes 1 month ago
      A user with AGA uses topical spironolactone 2% due to side effects from the oral form and is concerned about its use during conception and breastfeeding. They seek alternatives to prevent AGA relapse while planning pregnancy and after childbirth.

      community spironolactone pills to topical

      in Research/Science  6 upvotes 1 month ago
      Crushing spironolactone pills and combining them with minoxidil for topical application may be effective for hair loss, with the addition of finasteride suggested. Adding rosemary and peppermint oils can help mask the unpleasant smell.

      community Does the effect of spironolactone on androgenetic alopecia really weaken over time?

      in Female  4 upvotes 4 months ago
      Spironolactone can remain effective for a long time in treating androgenetic alopecia, but it may not completely stop hair loss. Hair loss treatments like spironolactone, finasteride, and dutasteride slow down hair loss rather than cure it, and their effectiveness can vary based on individual response and the aggressiveness of the condition.

    Related Research

    7 / 7 results