Therapeutic Effect of Spironolactone in Hyperandrogenism Syndrome

The document discussed the therapeutic effects of spironolactone (SL) in treating hyperandrogenism syndrome, including conditions like hirsutism, acne, seborrhea, and androgenic alopecia. SL was effective in reducing symptoms by blocking androgen receptors, inhibiting 5α-reductase activity, and influencing steroid metabolism. Clinical studies showed significant improvements in hirsutism, acne, and hair growth, with one study reporting a 47% reduction in hirsutism scores after 6 months of treatment. However, side effects such as gynecomastia in men, menstrual irregularities in women, and gastrointestinal and central nervous system disturbances were noted. The document emphasized the need for effective antiandrogenic treatments and the potential of SL, despite limited availability and research in the Soviet Union at the time.