Therapeutic Effect of Spironolactone in Hyperandrogenism Syndrome

    January 1993 in “ Проблемы Эндокринологии ”
    Д. Е. Шилин, И И Дедов, Е. А. Григорьева
    Image of study
    TLDR Spironolactone effectively reduces symptoms of hyperandrogenism but has some side effects.
    The document discussed the therapeutic effects of spironolactone (SL) in treating hyperandrogenism syndrome, including conditions like hirsutism, acne, seborrhea, and androgenic alopecia. SL was effective in reducing symptoms by blocking androgen receptors, inhibiting 5α-reductase activity, and influencing steroid metabolism. Clinical studies showed significant improvements in hirsutism, acne, and hair growth, with one study reporting a 47% reduction in hirsutism scores after 6 months of treatment. However, side effects such as gynecomastia in men, menstrual irregularities in women, and gastrointestinal and central nervous system disturbances were noted. The document emphasized the need for effective antiandrogenic treatments and the potential of SL, despite limited availability and research in the Soviet Union at the time.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 607 results

      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  35 upvotes 6 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community I wish I were a man so bad. Life is cruel

      in Female  221 upvotes 2 weeks ago
      A woman with androgenetic alopecia uses Dutasteride and Bicalutamide but feels devastated due to increased sensitivity to DHT. She considers wigs, Minoxidil, and seeks advice on options like spironolactone, hair transplants, and therapy.

      community Spironolactine Update: 2 months (34, Female)

      in Female  23 upvotes 9 years ago
      A female user's experience using Spironolactone to treat Female Pattern Hair Loss (FPHL) and Androgenic Alopecia, as well as discussing the effectiveness of the drug at different dosages.

      community I wish we didn’t have to live with this….

       61 upvotes 6 years ago
      The struggles of hair loss at a young age and available treatments, such as medication (Finasteride, Minoxidil, Dutasteride, Derma Rolling) and potential options for hair systems or cloning in Japan. People discussed their own experiences with trying to cope with the emotional aspects of this condition.

    Related Research

    8 / 8 results