The inflammatory component of androgenetic alopecia
February 2022
in “Journal of The American Academy of Dermatology”
TLDR Androgenetic alopecia, a genetic disorder affecting up to 50% of adults, is caused by an excessive response to androgens leading to hair follicle shrinkage. Treatments include FDA-approved drugs, other therapies like low-dose oral minoxidil, and hair transplantation.
Androgenetic alopecia (AGA) is a genetic disorder that may affect up to 50% of adults, characterized by an excessive response to androgens. This leads to higher production of dihydrotestosterone and increased levels of 5 α-reductase and androgen receptors in the balding scalp. The excessive activation of these receptors results in follicular miniaturization through a progressively shorter anagen phase. Currently, only two FDA-approved drugs exist for AGA treatment: topical minoxidil and oral finasteride. Other therapies such as low-dose oral minoxidil, dutasteride, spironolactone, platelet-rich plasma, red light, and 660-nm laser have shown some efficacy. Hair transplantation can also be effective for suitable candidates.
View this study on jaad.org →
Cited in this study
research Perifollicular inflammation and follicular spongiosis in androgenetic alopecia
Hair loss in both Androgenetic Alopecia and Alopecia Areata is often accompanied by inflammation around hair follicles, but the location and severity of this inflammation varies.
research At the crossroads of 2 alopecias: Androgenetic alopecia pattern of hair regrowth in patients with alopecia areata treated with oral Janus kinase inhibitors
JAK inhibitors help hair regrowth but not fully effective for androgenetic alopecia.
research Androgenetic alopecia and microinflammation
Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.
Related
research The inflammatory component of androgenetic alopecia
Androgenetic alopecia, a genetic disorder affecting up to 50% of adults, is caused by an excessive response to androgens leading to hair follicle shrinkage. Treatments include FDA-approved drugs, other therapies like low-dose oral minoxidil, and hair transplantation.
research Minoxidil to Treat Androgenetic Alopecia in Men and Women: What is It & How does It Work?
Minoxidil, originally a blood pressure medication, is effective in treating hair loss in men and women, with different strengths recommended for each.
research 한국인의 두피모발 특성과 남성형탈모증
The document's conclusion cannot be provided because the text is in Korean and cannot be parsed.
research Androgenetic alopecia: pathogenesis and potential for therapy
Hair loss needs more research for better treatments.